Chlorhexidine-encapsulated mesoporous silica-modified dentin adhesive.
Chlorhexidine-encapsulated mesoporous silica-modified dentin adhesive.
复制标题
氯己定封装介孔二氧化硅改性牙本质粘合剂。
DOI：
10.1016/j.jdent.2018.08.012
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发表时间：
2018
影响因子：
4.4
通讯作者：
Huang Cui
中科院分区：
文献类型：
--
作者：
Yan Huiyi;Wang Shilei;Han Lin;Peng Wenan;Yi Luyao;Guo Rui;Liu Siying;Yang Hongye;Huang Cui
目的通过对牙本质粘接剂-牙本质界面的理化性质和抗菌性能的评价，探讨氯己定包裹的介孔二氧化硅(CHX@PMSN)作为商品牙科粘接剂改性剂的可行性。方法将CHX@PMSN按4种质量分数(0、1、5和10 wt.%)加入到商品粘接剂中，制备医用粘结剂。综合评价了其对变形链球菌生物被膜的抗菌能力、转化率、黏附形态、微拉伸结合强度(MTBS)和纳米渗漏的表达。变形生物膜生长，而CHX从改性粘合剂中持续释放。在1%和5%的浓度下，CHX@pMSN的加入对即刻粘结强度没有影响(P&gT； 0.05)。胶原酶老化1个月后，5%CHX@pMSN组主要保存了这些键。同时，CHX@pMSN掺杂粘结剂的纳米渗漏分布与对照组相似。结论本研究表明，5%的CHX@pMSN改性粘结剂在不影响即时粘接强度、抗胶原酶老化和有效抑制OFS之间取得了平衡。临床意义CHX@pMSN改性牙本质粘接剂可潜在地延长粘接剂在临床上的使用寿命。
ObjectivesThis work aims to explore the feasibility of chlorhexidine-encapsulated mesoporous silica (CHX@pMSN) as a modifier of a commercial dental adhesive via the evaluation of physicochemical properties and antibacterial capabilities of adhesive–dentin interface.MethodsTherapeutic adhesives were developed in the present study by incorporating CHX@pMSN into a commercial adhesive at four mass fractions (0, 1, 5 and 10 wt.%). The antibacterial capability onStreptococcus mutans(S. mutans)biofilm, conversion degree, adhesive morphology, microtensile bond strength (MTBS) and nanoleakage expression were evaluated comprehensively.ResultsMTT and CLSM evaluation showed that CHX@pMSN-doped adhesive inhibitsS. mutansbiofilm growth, while CHX is released from the modified adhesive continuously. The incorporation of CHX@pMSN did not affect immediate bond strength at the concentration of 1% and 5% (P> 0.05). Moreover, these bonds were mainly preserved in 5% CHX@pMSN group after one month of collagenase ageing. Meanwhile, CHX@pMSN-doped adhesive groups exhibited similar nanoleakage distribution compared with the control.ConclusionThis study showed that the 5% CHX@pMSN-modified adhesive achieved balance amongst unaffected immediate bonding strength, well-preserved bonds against collagenase ageing and effective inhibition ofS. mutansbiofilm growth.Clinical significanceCHX@pMSN-modified dentin adhesive can potentially extend the service life of adhesive restoration in clinic.