Early responses to intravitreal ranibizumab in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
Early responses to intravitreal ranibizumab in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
复制标题
典型的新生血管相关的黄斑变性和多型脉络膜脉络膜病变的玻璃体内ranibizumab的早期反应。
DOI：
10.1155/2011/742020
复制
发表时间：
2011
影响因子：
1.9
通讯作者：
Negi A
中科院分区：
文献类型：
--
作者：
Matsumiya W;Honda S;Bessho H;Kusuhara S;Tsukahara Y;Negi A
目的。评估两种不同表型的年龄相关性黄斑变性（AMD）：典型的新生血管性AMD （tAMD）和息肉样脉络膜血管病变（PCV）的玻璃体内雷尼单抗（IVR）的早期反应。方法。60例患者共60只眼（tAMD 28只，PCV 32只）。每月进行3次IVR治疗（0.5 mg）。比较tAMD组和PCV组最佳矫正视力（BCVA）和视网膜中央厚度（CRT）的变化。结果。tAMD组的平均BCVA logMAR在初始IVR后的第1个月和第3个月显著改善，但PCV组没有变化。在初始IVR后的3个月内，两种表型在CRT中均显示出显着改善。与PCV组相比，tAMD组在CRT的改善方面没有显著差异。在逐步分析中，较差的BCVA预处理和tAMD病变在初始IVR后3个月显著有利于BCVA的更大改善。结论。在BCVA改善方面，tAMD表型对IVR的早期反应明显优于PCV。
Purpose. To evaluate the early response to intravitreal ranibizumab (IVR) in two different phenotypes of age-related macular degenerations (AMD): typical neovascular AMD (tAMD) and polypoidal choroidal vasculopathy (PCV). Methods. Sixty eyes from 60 patients (tAMD 28, PCV 32 eyes) were recruited. Three consecutive IVR treatments (0.5 mg) were performed every month. Change in the best-corrected visual acuity (BCVA) and central retinal thickness (CRT) was then compared between the tAMD and PCV groups. Results. The mean BCVA logMAR was significantly improved at month 1 and month 3 after the initial IVR in the tAMD group, but there was no change in the PCV group. Both phenotypes showed significant improvements in the CRT during the 3 months after the initial IVR. There were no significant differences in the improvements of the CRT in the tAMD versus the PCV group. In the stepwise analysis, a worse pretreatment BCVA and tAMD lesions were significantly beneficial for a greater improvement of BCVA at 3 months after the initial IVR. Conclusions. The phenotype of tAMD showed a significantly better early response to IVR than PCV in terms of BCVA improvement.
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DOI：
10.1007/s00417-008-0995-0
发表时间：
2009-03-01
影响因子：
2.7
作者：
Konstantinidis, Lazaros;Mantel, Irmela;Ambresin, Aude
通讯作者：
Ambresin, Aude
影响因子：
158.5
作者：
Rosenfeld, Philip J.;Brown, David M.;Kim, Robert Y.
通讯作者：
Kim, Robert Y.
影响因子：
2.4
作者：
Honda, Shigeru;Kurimoto, Yasuo;Uenishi, Mamoru
通讯作者：
Uenishi, Mamoru
影响因子：
1.7
作者：
Reche-Frutos, J.;Calvo-Gonzalez, C.;Garcia-Sanchez, J.
通讯作者：
Garcia-Sanchez, J.
影响因子：
2.6
作者：
Carneiro, Angela M.;Silva, Rufino M.;Falcao-Reis, Fernando M.
通讯作者：
Falcao-Reis, Fernando M.