Prostaglandins and inflammation.
Prostaglandins and inflammation.
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DOI：
10.1161/atvbaha.110.207449
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
FitzGerald GA
中科院分区：
文献类型：
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作者：
Ricciotti E;FitzGerald GA
前列腺素是从花生四烯酸衍生的脂质类物质。它们都维持稳态功能并介导致病机制，包括炎症反应。它们是通过环氧合酶（考克斯）同工酶的作用由花生四烯酸产生的，其生物合成被非甾体抗炎药（NSAID）（包括选择性抑制考克斯-2的药物）阻断。尽管NSAID具有临床疗效，但野牡丹素可能在促进和缓解炎症方面发挥作用。本文综述了前列腺素产生的机制以及单个介质及其受体在调节炎症反应中的作用。前列腺素生物学与动脉粥样硬化、血管损伤反应和主动脉瘤具有潜在的临床相关性。
Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. They are generated from arachidonate by the action of cyclooxygenase (COX) isoenzymes and their biosynthesis is blocked by nonsteroidal anti-inflammatory drugs (NSAIDs), including those selective for inhibition of COX-2. Despite the clinical efficacy of NSAIDs, prostaglandins may function in both the promotion and resolution of inflammation. This review summarizes insights into the mechanisms of prostaglandin generation and the roles of individual mediators and their receptors in modulating the inflammatory response. Prostaglandin biology has potential clinical relevance for atherosclerosis, the response to vascular injury and aortic aneurysm.