Chiral guanosine 5'-monophosphate-capped gold nanoflowers: Controllable synthesis, characterization, surface-enhanced Raman scattering activity, cellular imaging and photothermal therapy
Chiral guanosine 5'-monophosphate-capped gold nanoflowers: Controllable synthesis, characterization, surface-enhanced Raman scattering activity, cellular imaging and photothermal therapy
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DOI：
10.1007/s12274-012-0248-8
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发表时间：
2012-09-01
期刊：
影响因子：
9.9
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Huang, Peng;Pandoli, Omar;Chen, Xiaoyuan
金属纳米材料中的等离子体和手性是耐人寻味和鼓舞人心的现象。金属纳米材料的纳米手性是近几年来研究的热点。通常，由于较大尺寸的纳米材料(>；10 nm)等离子体激元诱导的圆二色(CD)响应的原位产生并不容易，因此大多数纳米材料(>；10 nm)的等离子体激元诱导圆二色(CD)响应都是通过用手性试剂修饰预制的非手性纳米材料而人工产生的。本文报道了在手性鸟苷5‘-磷酸(5’-GMP)和手性还原剂L-抗坏血酸(L-AA)存在的手性还原环境中，一锅绿色合成具有丰富花瓣状尖端的手性金纳米花的方法。不同的还原剂会影响产品的形状和手性。此外，可以通过调节反应时间来控制GNFS的大小和手性。所合成的纳米纳米纤维具有良好的生物相容性，可用于表面增强拉曼散射(SERS)增强、细胞暗视野成像和光热治疗。
Plasmonics and chirality in metal nanomaterials are intriguing and inspiring phenomena. Nanoscale chirality of metal nanomaterials has emerged as a hot topic in the past several years. Generally, most plasmon-induced circular dichroism (CD) responses of nanomaterials (> 10 nm) have been artificially created by modifying pre-made achiral nanomaterials with chiral agents, because the in situ generation of plasmon-induced CD responses of nanomaterials with larger size (> 10 nm) is not easy. Herein, we report a simple one-pot green synthesis of chiral gold nanoflowers (GNFs) with abundant petal-shaped tips in the chiral reduction environment arising from the presence of chiral guanosine 5'-monophosphate (5'-GMP) and the chiral reducing agent L-ascorbic acid (L-AA). Different reducing agents can impact the shape and chirality of the products. In addition, the size and chirality of the GNFs can be controlled by adjusting the reaction time. The as-synthesized GNFs have good biocompatibility and can be used for surface-enhanced Raman scattering (SERS) enhancement, cellular dark-field imaging and photothermal therapy.