Incidence of breast cancer among postmenopausal, hypertensive women
Incidence of breast cancer among postmenopausal, hypertensive women
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DOI：
10.1002/ijc.22689
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发表时间：
2007-08-01
影响因子：
6.4
通讯作者：
Nissinen, Aulikki
中科院分区：
文献类型：
--
作者：
Lindgren, Annamarja;Pukkala, Eero;Nissinen, Aulikki
血压升高被认为是乳腺癌的一个危险因素，但结果仍然存在争议。在这项研究中，通过芬兰癌症登记处评估了9，112名绝经后高血压妇女的乳腺癌发病率，这些妇女被纳入北卡累利阿项目的社区高血压登记册。平均随访时间为27年。在我们的队列中，高血压女性乳腺癌的发病率与芬兰东部特定年龄和特定时期人群的发病率相似[标准化发病率比为0.96（95%置信区间为0.86-1.05）]。在考克斯回归分析中，当考虑所有女性时，血压水平或抗高血压（AH）药物的使用与乳腺癌发病率之间没有关联。基线时AH药物的使用与舒张压（DBP）之间存在统计学显著性相互作用。在基线时未使用AH药物的女性中，DBP水平与随后的乳腺癌风险呈正相关（风险比1.26/10 mm Hg，95%置信区间1.06-1.46）。在基线时使用AH药物的女性中，DBP具有临界显著性的相反效应（风险比0.90/10 mm Hg，95%置信区间0.78-1.01）。总之，绝经后高血压患者的乳腺癌发病率与一般人群没有差异。DBP水平升高可能与未接受过乳腺癌治疗的女性患乳腺癌的风险增加有关。(c)2007 Wiley-Liss，Inc.
Elevated blood pressure has been proposed to be a risk factor for breast cancer but the results remain controversial. In this study, the incidence of breast cancer among 9,112 postmenopausal, hypertensive women included in the community-based hypertension register of the North Karelia project was assessed through the Finnish Cancer Registry. The mean follow-up time was 27 years. The incidence of breast cancer in hypertensive women in our cohort was similar to the age and period specific population-based rates for Eastern Finland [the standardised incidence ratio 0.96 (95% confidence interval 0.86-1.05)]. In the Cox regression analysis, there was no association between blood pressure levels, or use of antihypertensive (AH) drugs, and breast cancer incidence, when all women were considered. There was a statistically significant interaction of the use of AH drugs at baseline and the diastolic blood pressure (DBP). Among women who were not using AH drugs at baseline, the DBP level was positively associated with the subsequent risk of breast cancer (hazard ratio 1.26/10 mm Hg, 95% confidence interval 1.06-1.46). In women with AH drugs at baseline, the DBP had an opposite effect of borderline significance (hazard ratio 0.90/10 mm Hg, 95% confidence interval 0.78-1.01). In conclusion, breast cancer incidence among postmenopausal hypertensive patients in general does not differ from that of general population. Elevated DBP levels may be associated with an increased breast cancer risk among nonpharmacologically treated women. (c) 2007 Wiley-Liss, Inc.