MRI reveals structural abnormalities in patients with idiopathic generalized epilepsy
MRI reveals structural abnormalities in patients with idiopathic generalized epilepsy
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DOI：
10.1212/01.wnl.0000233886.55203.bd
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发表时间：
2006-09-12
期刊：
影响因子：
9.9
通讯作者：
Cendes, F.
中科院分区：
文献类型：
--
作者：
Betting, L. E.;Mory, S. B.;Cendes, F.
目的：评价特发性全身性癫痫患者的MRI表现。方法：根据国际抗癫痫联盟推荐的临床和脑电图标准诊断特发性广泛性癫痫。采用先前建立的癫痫方案，在2.0 T扫描仪上进行MRI。检查图像，并报告任何异常。患者被分为有和没有MRI异常的两组。比较两组患者的年龄、癫痫发作年龄、亚综合征、脑电图结果和癫痫控制情况。结果：在134例mri中，33例（24%）显示异常，其中大多数（88%）是非特异性的。蛛网膜囊肿、弥漫性皮质萎缩、基底节区异常（信号改变及血管周围间隙突出）、脑室异常（单侧或双侧侧脑室体积增加）、白质异常（额叶T2信号增加）、海马体积减小、局灶性脑回异常、额叶胶质细胞增生等8种主要异常。组间比较显示MRI异常患者脑电图病灶比例较高，与MRI异常位置基本一致。结论：24%的特发性全身性癫痫患者有MRI异常。然而，这些异常大多是非特异性的。
Objective: To evaluate MRI findings in a large group of patients with idiopathic generalized epilepsies. Methods: Idiopathic generalized epilepsies were diagnosed according to clinical and EEG criteria following International League Against Epilepsy recommendations. MRI was performed in a 2.0 T scanner using a previously established epilepsy protocol. Images were reviewed, and any abnormality was reported. Patients were divided in those with and without MRI abnormalities. Comparisons were made between these groups concerning age, age at seizure onset, subsyndrome, EEG findings, and seizure control. Results: Of the 134 MRIs evaluated, 33 (24%) showed abnormalities, most of which (88%) were nonspecific. There were eight main abnormalities: arachnoid cyst, diffuse cortical atrophy, basal ganglia abnormalities (signal alterations and prominent perivascular spaces), ventricular abnormalities (uni- or bilateral increased volume of the lateral ventricles), white matter abnormalities (increased T2 signal in the frontal lobes), reduced hippocampal volume, focal gyral abnormality, and area of gliosis in the frontal lobe. Comparisons between the groups showed a higher proportion of EEG focalities in patients with abnormal MRI, which were in most part concordant with the location of the MRI abnormalities. Conclusions: Twenty-four percent of patients with idiopathic generalized epilepsies had MRI abnormalities. However, the majority of these abnormalities were nonspecific.