Transgenic Rat Models of Huntington's Disease
Transgenic Rat Models of Huntington's Disease
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DOI：
10.1007/7854_2013_245
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Temel, Yasin
中科院分区：
文献类型：
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作者：
Carreira, Joao Casaca;Jahanshahi, Ali;Temel, Yasin
为了研究疾病机制并评估新疗法的效力，已经创建了几种亨廷顿病 (HD) 动物模型。在这里，我们描述了两种转基因大鼠模型的特征：HD转基因大鼠模型（片段模型）和细菌人工染色体HD模型（全长模型）。我们讨论它们的遗传、行为、神经病理学和神经生理学特征。
Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.