Oxazolidinone-Promoted, Torquoselective Nazarov Cyclizations
Oxazolidinone-Promoted, Torquoselective Nazarov Cyclizations
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DOI：
10.1021/ol300316a
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发表时间：
2012-04-06
期刊：
影响因子：
5.2
通讯作者：
Flynn, Bernard L.
中科院分区：
文献类型：
--
作者：
Kerr, Daniel J.;Miletic, Michael;Flynn, Bernard L.
恶唑烷酮类化合物是纳扎罗夫反应的有力促进剂，能够在温和的条件下实现常规抗性底物的环化反应。它们在传统的得到环戊酮的纳扎罗夫反应和“中断的”纳扎罗夫反应中都发挥了很好的区域和扭矩选择性控制，得到了更多高取代多立体中心的产物。
Oxazolidinones are powerful promoters of the Nazarov reaction, enabling the cyclization of conventionally resistant substrates to be achieved under mild conditions. They exert excellent regio- and torquoselective control in both the conventional Nazarov reaction giving cyclopentenones and in the "interrupted" Nazarov reaction, giving more highly substituted multistereocenter containing products.