Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children
Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children
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DOI：
10.1111/j.1365-2222.2009.03234.x
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发表时间：
2009-06-01
影响因子：
6.1
通讯作者：
Virtanen, S. M.
中科院分区：
文献类型：
--
作者：
Erkkola, M.;Kaila, M.;Virtanen, S. M.
众所周知，维生素D具有多种免疫作用，它可能在预防过敏性疾病方面发挥作用。研究孕妇在妊娠期间摄入维生素D对hla - dqb1致1型糖尿病易感性儿童5岁前出现哮喘、过敏性鼻炎（AR）和特应性湿疹的影响。参与以人群为基础的出生队列研究的儿童（1669名）随访5年，通过有效问卷评估哮喘、AR和特应性湿疹。通过食物频率问卷对产妇饮食进行评估。母亲从食物中摄入的维生素D平均为5.1 μ g（标准差2.6），从补充剂中摄入的维生素D平均为1.4 μ g（标准差2.6）。只有32%的女性服用维生素D补充剂。校正潜在混杂因素后，母亲从食物中摄取维生素D与哮喘风险呈负相关[危险比（HR） 0.80；95%置信区间（CI） 0.64-0.99]和AR [HR 0.85；95% ci 0.75-0.97]。单独补充维生素D与任何结果无关。调整母亲摄入的其他饮食因素并没有改变结果。孕妇在怀孕期间从食物中摄取维生素D可能与儿童期哮喘和急性呼吸道反应的风险负相关。
Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases.To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes.Children (1669) participating in the population-based birth cohort study were followed for asthma, AR, and atopic eczema assessed by validated questionnaire at 5 years. Maternal diet was assessed by a food-frequency questionnaire.The mean maternal intake of vitamin D was 5.1 (SD 2.6) mu g from food and 1.4 (2.6) mu g from supplements. Only 32% of the women were taking vitamin D supplements. When adjusted for potential confounders, maternal intake of vitamin D from food was negatively related to risk of asthma [hazard ratio (HR) 0.80; 95% confidence interval (CI) 0.64-0.99] and AR [HR 0.85; 95% CI 0.75-0.97]. Vitamin D supplements alone were not associated with any outcome. Adjustment for maternal intake of other dietary factors did not change the results.Maternal vitamin D intake from foods during pregnancy may be negatively associated with risk of asthma and AR in childhood.