COMPARATIVE ANATOMY OF THE VENTROMEDIAL MESENCEPHALIC TEGMENTUM IN THE RAT, CAT, MONKEY AND HUMAN
COMPARATIVE ANATOMY OF THE VENTROMEDIAL MESENCEPHALIC TEGMENTUM IN THE RAT, CAT, MONKEY AND HUMAN
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DOI：
10.1002/cne.902520402
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发表时间：
1986-10-22
影响因子：
2.5
通讯作者：
TORK, I
中科院分区：
文献类型：
--
作者：
HALLIDAY, GM;TORK, I
在大鼠、猫猴和人脑干的尼氏染色连续切片上研究了腹内侧中脑被盖（VMT）的五组分核。建立了MT核的模型来比较它们在不同物种间的大小、形状和分布。计算每个物种每个细胞核的体积、神经元数量、神经元的大小分布、平均体细胞大小和神经元的堆积密度。还描述了不同细胞核中细胞的形态。臂旁色素核（PBP）平均占VMT体积和细胞数量的51%。旁核（PN）和中央线状核（LC）分别占VMT体积和细胞数的19%和14%。相对较小但致密的束间核（IF）平均占VMT体积和细胞数量的9%，吻侧线状核（LR）占剩余的7%。然而，在不同的物种中，相对突出在物种之间是不同的。因此PBP在猴子的VMT细胞核中是最大的，PN在人类中发育得特别好，IF在大鼠中含有特别多的细胞，而LR和LC在猫中强烈发育。本研究提出了每个物种的五个细胞核的细胞结构描述。每个细胞核独特的细胞结构外观表明它们的功能可能不同。有证据表明，VMT核的投射是有差异的，这一可能性得到了加强，在解释使用VMT区域的刺激和/或损伤实验的实验研究结果以及解释人脑的病理结果时，可能需要考虑到这种可能性。
The five component nuclei of the ventromedial mesencephalic tegmentum (VMT) were studied on Nissl stained serial sections of the brain stem of rat, cat monkey (Macaca nemestrina) and human. Models of the MT nuclei were constructed to compare their size, shape and disposition across species. For each nucleus in each species the following were calculated: the volume, the number of neurons, the size distribution of neurons, the mean soma size and the packing density of neurons. The morphology of the cells in the different nuclei is also described. The parabrachial pigmented nucleus (PBP), forms, on average, 51% of the VMT volume and cell number. The paranigral nucleus (PN) and the central linear nucleus (LC) formed 19% and 14% of the VMT volume and cell number respectively. The relatively small, but compact interfascicular nucleus (IF) was on average 9% of the VMT volume and cell number and the rostral linear nucleus (LR) formed its remaining 7%. However, in different species the relative prominence varies between species. Thus PBP is the largest of the VMT nuclei in the monkey, PN is particularly well developed in the human, IF contains a particularly large number of cells in the rat, and LR and LC are strongly developed in the cat. This study presents a cytoarchitectonic description of the five nuclei in each species. The distinctive cytoarchitectonic appearance of each nucleus suggests that their functions may differ. This possibility, which is strenghtened by evidence that the projections of the VMT nuclei are differential, may need to be considered in the interpretation of the results of experimental investigations using stimulation and/or lesion experiments in the VMT region and in the interpretation of pathological findings in the human brain.