THE IMMUNE-SYSTEM EVOLVED TO DISCRIMINATE INFECTIOUS NONSELF FROM NONINFECTIOUS SELF
THE IMMUNE-SYSTEM EVOLVED TO DISCRIMINATE INFECTIOUS NONSELF FROM NONINFECTIOUS SELF
复制标题
DOI：
10.1016/0167-5699(92)90198-g
复制
发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
JANEWAY, CA
中科院分区：
文献类型：
--
作者：
JANEWAY, CA
在这里，查尔斯·扬维（Charles Janeway）认为，两个信号启动适应性免疫反应的要求可能反映了宿主防御的进化历史。宿主防御的早期阶段涉及受体和配体，这些受体和配体可能在重新排列基因中编码的克隆分布受体发展之前可能控制了免疫反应。前者在当代脊椎动物中持续存在，以引发先天或非克隆反应，并向淋巴细胞发出信号，表明特定抗原与微生物有关。
Here, Charles Janeway argues that the requirement for two signals to initiate the adaptive immune response may reflect the evolutionary history of host defences. Early phases of host defence involve receptors and ligands that may have controlled immune responses prior to the development of clonally-distributed receptors encoded in rearranging genes. The former receptors persist in contemporary vertebrates both to trigger innate or nonclonal responses and to signal to lymphocytes that a particular antigen is associated with a microorganism.