A PLATELET-INHIBITOR-DRUG TRIAL IN CORONARY-ARTERY BYPASS OPERATIONS - BENEFIT OF PERIOPERATIVE DIPYRIDAMOLE AND ASPIRIN THERAPY ON EARLY POSTOPERATIVE VEIN-GRAFT PATENCY
A PLATELET-INHIBITOR-DRUG TRIAL IN CORONARY-ARTERY BYPASS OPERATIONS - BENEFIT OF PERIOPERATIVE DIPYRIDAMOLE AND ASPIRIN THERAPY ON EARLY POSTOPERATIVE VEIN-GRAFT PATENCY
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DOI：
10.1056/nejm198207083070201
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
DANIELSON, GK
中科院分区：
文献类型：
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作者：
CHESEBRO, JH;CLEMENTS, IP;DANIELSON, GK
为了预防冠状动脉旁路移植术后闭塞，一项前瞻性随机双盲试验在407例患者中比较了双嘧达莫（术前2天开始）加阿司匹林（术后7小时添加）与安慰剂。360例患者（88%）在6个月内进行了静脉移植血管造影。手术时间（中位数，8天）。1个月内。在手术中，治疗组中3%的静脉移植物远端闭塞（351例中的10例），安慰剂组中10%（362例中的38例）;治疗组中1个或多个远端闭塞的患者比例为8%（130例中的10例），安慰剂组中21%（130例中的27例）。在> 50个亚组中，移植物通畅性的这种益处持续存在。两组的术后早期出血相似。在这项试验中，潘生丁和阿司匹林在术后早期预防移植物闭塞是有效的。
To prevent occlusion of aortocoronary-artery-bypass grafts, a prospective, randomized double-blind trial compared dipyridamole (instituted 2 days before operation) plus aspirin (added 7 h after operation) with placebo in 407 patients. Vein-graft angiography was performed in 360 patients (88%) within 6 mo. of operation (median, 8 days). Within 1 mo. of operation, 3% of vein-graft distal anastomoses (10 of 351) were occluded in the treated patients and 10% (38 of 362) in the placebo group; the proportion of patients with 1 or more distal anastomoses occluded was 8% (10 of 130) in the treated group and 21% (27 of 130) in the placebo group. This benefit in graft patency persisted in each of > 50 subgroups. Early postoperative bleeding was similar in the 2 groups. In this trial dipyridamole and aspirin were effective in preventing graft occlusion early after operation.