Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder
Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder
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DOI：
10.1016/s0006-3223(01)01218-5
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发表时间：
2001-12-15
影响因子：
10.6
通讯作者：
Reiss, AL
中科院分区：
文献类型：
--
作者：
Carrion, VG;Weems, CF;Reiss, AL
背景：体积成像研究显示，与匹配的对照组相比，创伤后应激障碍(PTSD)成人患者的脑形态发生了异常。方法：对24名7-14岁有创伤和创伤后应激障碍症状的儿童进行临床医生应用创伤后应激障碍评定量表(CAPS-CA)评定。样品在1.5T扫描仪中进行磁共振成像。结果：与对照组相比，临床组额叶不对称性减弱，脑和脑体积缩小。结论：额叶异常可能是儿童创伤后应激障碍的结果，也可能是该年龄段儿童发生该综合征的一个危险因素。讨论了这些发现的含义以及它们与以前的研究的一致性。生物精神病学2001；50：943-951(C)2001生物精神病学学会。
Background: Volumetric imaging research has shown abnormal brain morphology in adults with posttraumatic stress disorder (PTSD) when compared with matched control subjects. In this article, we present brain imaging findings from a study of children with PTSD symptoms.Methods: Twenty-four children between the ages of 7 and 14 with a history of trauma and PTSD symptoms were assessed with the Clinician-Administered PTSD Scale for Children and Adolescents (CAPS-CA). The sample underwent magnetic resonance imaging in a 1.5 T scanner. Brain images were analyzed by raters blind to diagnostic status using well-standardized methods, and images were compared with age- and gender-matched healthy control subjects.Results: The clinical group demonstrated attenuation of frontal lobe asymmetry and smaller total brain and cerebral volumes when compared with the control group. There were no statistically significant differences in hippocampal volume between clinical and control subjects.Conclusions: Frontal lobe abnormalities may occur as a result of PTSD in children or, alternatively, be a risk factor for the development of the syndrome in this age group. The implications of the findings and their consistency with previous research are discussed. Biol Psychiatry 2001;50:943-951 (C) 2001 Society of Biological Psychiatry.