Updated classification of norovirus genogroups and genotypes
Updated classification of norovirus genogroups and genotypes
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DOI：
10.1099/jgv.0.001318
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发表时间：
2019-10-01
影响因子：
3.8
通讯作者：
Vinje, Jan
中科院分区：
文献类型：
--
作者：
Chhabra, Preeti;de Graaf, Miranda;Vinje, Jan
诺如病毒是与哺乳动物急性胃肠炎相关的遗传多样性的RNA病毒。根据VP1全基因的氨基酸多样性和ORF1的RNA依赖RNA聚合酶(RdRp)区的核苷酸多样性，可将其分为不同的基因群和P(聚合酶)组。近年来，报告了几种新的诺如病毒，需要更新现有的分类方案。使用前面描述的2倍标准差(SD)标准将序列分组为单独的聚类，我们将基因组数扩大到10(GI-GX)，将GVII、GVIII、GIX[以前的GII]的基因组数扩大到49个(9个GI、27个GII、3个GIII、2个GIV、2个GV、2个GVI和1个基因型。15]和GX)。目前在公共数据库中只有一个序列的病毒被划分为暂定的新基因组组(GNA1和GNA2)和基因型(GII)。NA1，Gii.Na2和GIV。NA1)，它们的最终任务等待额外的相关序列。根据RdRp区核苷酸多样性，诺如病毒可分为60个P型(14个GI、37个GII、2个GIII、1个GIV、2个GV、2个GVI、1个GVII和1个GX)，2个暂定P-群和14个暂定P-型。未来的分类和命名更新将基于完整的基因组序列，并将由国际诺沃克病毒分类工作组协调和传播。
Noroviruses are genetically diverse RNA viruses associated with acute gastroenteritis in mammalian hosts. Phylogenetically, they can be segregated into different genogroups as well as P (polymerase)-groups and further into genotypes and P-types based on amino acid diversity of the complete VP1 gene and nucleotide diversity of the RNA-dependent RNA polymerase (RdRp) region of ORF1, respectively. In recent years, several new noroviruses have been reported that warrant an update of the existing classification scheme. Using previously described 2x standard deviation (SD) criteria to group sequences into separate clusters, we expanded the number of genogroups to 10 (GI-GX) and the number of genotypes to 49 (9 GI, 27 GII, 3 GIII, 2 GIV, 2 GV, 2 GVI and 1 genotype each for GVII, GVIII, GIX [formerly GII. 15] and GX). Viruses for which currently only one sequence is available in public databases were classified into tentative new genogroups (GNA1 and GNA2) and genotypes (GII. NA1, GII. NA2 and GIV. NA1) with their definitive assignment awaiting additional related sequences. Based on nucleotide diversity in the RdRp region, noroviruses can be divided into 60 P-types (14 GI, 37 GII, 2 GIII, 1 GIV, 2 GV, 2 GVI, 1 GVII and 1 GX), 2 tentative P-groups and 14 tentative P-types. Future classification and nomenclature updates will be based on complete genome sequences and will be coordinated and disseminated by the international norovirus classification-working group.