Tissue perfusion rate estimation with compression-based photoacoustic-ultrasound imaging
Tissue perfusion rate estimation with compression-based photoacoustic-ultrasound imaging
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DOI：
10.1117/1.jbo.23.1.016010
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发表时间：
2018-01-01
影响因子：
3.5
通讯作者：
Zemp, Roger
中科院分区：
文献类型：
--
作者：
Choi, Min;Shapiro, A. M. James;Zemp, Roger
组织灌注对于运输血液氧气和营养物是必不可少的。组织灌注率的测量将在临床和临床前领域中具有显著影响。然而，很少有技术来成像这个重要的参数，它们通常需要造影剂。介绍了一种基于高频光声超声系统的组织压缩和成像的无标记方法，用于估计和可视化组织灌注率。实验表明，在不同温度暴露条件下，人类受试者的深度分辨灌注率存在统计学显著差异。(C)作者。由SPIE在知识共享署名3.0未移植许可下发布。
Tissue perfusion is essential for transporting blood oxygen and nutrients. Measurement of tissue perfusion rate would have a significant impact in clinical and preclinical arenas. However, there are few techniques to image this important parameter and they typically require contrast agents. A label-free methodology based on tissue compression and imaging with a high-frequency photoacoustic-ultrasound system is introduced for estimating and visualizing tissue perfusion rates. Experiments demonstrate statistically significant differences in depth-resolved perfusion rates in a human subject with various temperature exposure conditions. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.