The Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Nonischemic Dilated Cardiomyopathy
The Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Nonischemic Dilated Cardiomyopathy
复制标题
DOI：
10.1161/circulationaha.113.002518
复制
发表时间：
2013-10-08
期刊：
影响因子：
37.8
通讯作者：
Prasad, Sanjay K.
中科院分区：
文献类型：
--
作者：
Gulati, Ankur;Ismail, Tevfik F.;Prasad, Sanjay K.
背景：心血管磁共振是评价心脏功能的金标准技术。虽然左心室容量和射血分数是扩张型心肌病(DCM)预后的有力预测指标，但关于右室(RV)收缩功能不全(RVSD)的预后意义的数据有限。方法和结果我们前瞻性地研究了250例DCM患者的心血管磁共振检查结果。RVSD由右室射血分数45%定义，86例(34%)患者存在RVSD。在平均6.8年的随访期中，有52人死亡，7名患者接受了心脏移植。86例RVSD患者中42例和164例非RVSD患者中17例达到了全因死亡或心脏移植的主要终点(49%比10%；危险性比5.90；95%可信区间3.35~10.37；P
Background Cardiovascular magnetic resonance is the gold-standard technique for the assessment of ventricular function. Although left ventricular volumes and ejection fraction are strong predictors of outcome in dilated cardiomyopathy (DCM), there are limited data regarding the prognostic significance of right ventricular (RV) systolic dysfunction (RVSD). We investigated whether cardiovascular magnetic resonance assessment of RV function has prognostic value in DCM.Methods and Results We prospectively studied 250 consecutive DCM patients with the use of cardiovascular magnetic resonance. RVSD, defined by RV ejection fraction 45%, was present in 86 (34%) patients. During a median follow-up period of 6.8 years, there were 52 deaths, and 7 patients underwent cardiac transplantation. The primary end point of all-cause mortality or cardiac transplantation was reached by 42 of 86 patients with RVSD and 17 of 164 patients without RVSD (49% versus 10%; hazard ratio, 5.90; 95% confidence interval [CI], 3.35-10.37; P