R‐spondin signaling in the stomach: isthmal Lgr4 rules

R‐spondin signaling in the stomach: isthmal Lgr4 rules
复制标题

DOI：
10.15252/embj.2022111696
复制
发表时间：
2022-06
期刊：
The EMBO Journal
影响因子：
--
通讯作者：
E. Malagola;Y. Hayakawa;T. Wang
E. Malagola;Y. Hayakawa;T. Wang
中科院分区：
其他
文献类型：
--
作者：
E. Malagola;Y. Hayakawa;T. Wang

文献摘要

相似文献

R-spondins是胃上皮细胞的关键调节因子，Lgr 5受体历来被认为是其主要的信号转导子。Wizenty等人（2022）最近的工作揭示了Lgr 4和Lgr 5在H. pylori感染，揭示了胃再生过程中Rspo信号传导的复杂性，并提出了关于胃窦干细胞层次的问题。
R‐spondins are critical regulators of gastric epithelial cells, with Lgr5 receptor historically considered as their main signaling transducer. Recent work by Wizenty et al (2022) now revealed distinct roles for Lgr4 and Lgr5 in directing gland reconstitution following H. pylori infection, shedding new light on the complexities of Rspo signaling during gastric regeneration and raising questions about antral stem cell hierarchy.