The global burden of conduct disorder and attention-deficit/hyperactivity disorder in 2010
The global burden of conduct disorder and attention-deficit/hyperactivity disorder in 2010
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DOI：
10.1111/jcpp.12186
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发表时间：
2014-04-01
影响因子：
7.6
通讯作者：
Scott, James G.
中科院分区：
文献类型：
--
作者：
Erskine, Holly E.;Ferrari, Alize J.;Scott, James G.
2010年全球疾病负担研究（GBD 2010）是第一个将行为障碍（CD）和注意力缺陷/多动症（ADHD）纳入负担量化的研究。然后将患病率乘以残疾权重，以计算残疾生活年数（YLD）。由于没有发现CD或ADHD直接导致死亡的证据，因此未计算寿命损失年数（YLLs）。因此，残疾调整生命年（DADs）的数量等于YLDs.ResultsGlobally，CD负责575万YLDs/DADs负责进一步491500。总体而言，CD和ADHD占全球YLD总数的0.80%，占全球DLD总数的0.25%。就全球疾病而言，CD是第72大贡献者，是5- 19岁儿童的15大主要原因之一。在1990年和2010年之间，占人口增长和老龄化后，全球DADs归因于CD和ADHD保持稳定。适当分配资源以解决与CD和ADHD相关的高发病率问题，对于减轻全球负担是必要的。然而，由于缺乏所有四个流行病学参数的数据，以及在量化残疾方面存在方法上的挑战，负担估计受到限制。未来的研究需要解决这些局限性，以提高负担量化的准确性。
ObjectiveThe Global Burden of Disease Study 2010 (GBD 2010) is the first to include conduct disorder (CD) and attention-deficit/hyperactivity disorder (ADHD) for burden quantification.MethodA previous systematic review pooled the available epidemiological data for CD and ADHD, and predicted prevalence by country, region, age and sex for each disorder. Prevalence was then multiplied by a disability weight to calculate years lived with disability (YLDs). As no evidence of deaths resulting directly from either CD or ADHD was found, no years of life lost (YLLs) were calculated. Therefore, the number of disability-adjusted life years (DALYs) was equal to that of YLDs.ResultsGlobally, CD was responsible for 5.75 million YLDs/DALYs with ADHD responsible for a further 491,500. Collectively, CD and ADHD accounted for 0.80% of total global YLDs and 0.25% of total global DALYs. In terms of global DALYs, CD was the 72nd leading contributor and among the 15 leading causes in children aged 5-19years. Between 1990 and 2010, global DALYs attributable to CD and ADHD remained stable after accounting for population growth and ageing.ConclusionsThe global burden of CD and ADHD is significant, particularly in male children. Appropriate allocation of resources to address the high morbidity associated with CD and ADHD is necessary to reduce global burden. However, burden estimation was limited by data lacking for all four epidemiological parameters and by methodological challenges in quantifying disability. Future studies need to address these limitations in order to increase the accuracy of burden quantification.