ANTIPSORIATIC EFFECT OF FUMARIC-ACID DERIVATIVES - RESULTS OF A MULTICENTER DOUBLE-BLIND-STUDY IN 100 PATIENTS
ANTIPSORIATIC EFFECT OF FUMARIC-ACID DERIVATIVES - RESULTS OF A MULTICENTER DOUBLE-BLIND-STUDY IN 100 PATIENTS
复制标题
DOI：
10.1016/s0190-9622(94)70121-0
复制
发表时间：
1994-06-01
影响因子：
13.8
通讯作者：
JOSHI, RK
中科院分区：
文献类型：
--
作者：
ALTMEYER, PJ;MATTHES, U;JOSHI, RK
背景资料：寻常型银屑病可能受益于富马酸和/或其衍生物的治疗;然而，由于使用了不同的制剂，结果一直是矛盾的，难以解释。目的：本临床试验的目的是评估富马酸衍生物的治疗价值。方法：在银屑病患者中进行了一项随机双盲研究，将富马酸衍生物的良好表征制剂与安慰剂进行比较。结果表明富马酸衍生物在统计学上显著优于安慰剂。不良事件（潮红，胃肠道紊乱）最初相对频繁，但随后下降。结论富马酸衍生物被发现是有效和安全的治疗银屑病。
Background: Psoriasis vulgaris may benefit from treatment with fumaric acid and/or its derivatives; however, because different preparations have been used, results have been contradictory and difficult to interpret.Objective: The purpose of this clinical trial was to evaluate the therapeutic value of fumaric acid derivatives.Methods: A randomized double-blind study was carried out in patients with psoriasis, comparing a well-characterized formulation of fumaric acid derivatives with placebo.Results: The results indicated statistically significant superiority of the fumaric acid derivatives over placebo. Adverse events (flush, gastrointestinal disturbances) were initially relatively frequent, but decreased thereafter.Conclusion Fumaric acid derivatives were found to be effective and safe in the treatment of psoriasis.