ICl/AgNO3 Co-Catalyzed Radical Oxidation of Diaryl- and Alkylarylalkynes into 1,2-Diketones.
ICl/AgNO3 Co-Catalyzed Radical Oxidation of Diaryl- and Alkylarylalkynes into 1,2-Diketones.
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DOI：
10.1021/acs.joc.9b01667
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发表时间：
2019-08
期刊：
影响因子：
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通讯作者：
Wen Yang;Yu Chen;Yongqi Yao;Xin Yang;Qifu Lin;Dingqiao Yang
中科院分区：
文献类型：
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作者：
Wen Yang;Yu Chen;Yongqi Yao;Xin Yang;Qifu Lin;Dingqiao Yang
报道了一种新的ICl/AgNO3共催化二芳基和烷基芳基炔自由基氧化生成1,2-二酮的方法。该反应在温和的条件下进行顺利，并以中等至较高的产率生成1,2-二酮，对官能团具有良好的耐受性。所得的C4-（1,2-二酮芳基）异恶唑与1,2-二氨基苯能顺利反应生成C4-（3-芳基喹啉-2-基）异恶唑。最后，报道了以1,2-二苯乙炔和1,2-二氨基苯为原料，一锅法合成喹啉类化合物的新工艺。
A novel ICl/AgNO3 co-catalyzed radical oxidation of diaryl- and alkylarylalkynes into 1,2-diketones is reported. The reaction proceeded smoothly under mild conditions and generated 1,2-diketones in moderate to good yields with a good tolerance of functional groups. Furthermore, the obtained C4-(1,2-diketoaryl)isoxazoles could react smoothly with 1,2-diaminobenzene to form C4-(3-arylquinoxalin-2-yl)isoxazoles. At last, a new one-pot strategy for the synthesis of quinoxalines from 1,2-diphenylethynes and 1,2-diaminobenzene is also reported.