The human striatum in schizophrenia .2. Increased number of striatal neurons in schizophrenics
The human striatum in schizophrenia .2. Increased number of striatal neurons in schizophrenics
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DOI：
10.1016/s0925-4927(96)02947-2
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发表时间：
1997-02-07
影响因子：
2.3
通讯作者：
Lauer, M
中科院分区：
文献类型：
--
作者：
Beckmann, H;Lauer, M
在精神分裂症的神经病理学研究中，基底神经节的改变是一个主要课题。使用光学解剖器，我们对人类纹状体中的神经元和神经胶质细胞进行了无偏估计。为了排除年龄和性别的影响，9 名 65 岁以下的男性精神分裂症患者的大脑在年龄上与 9 名男性对照者的大脑非常匹配。比较两组之间纹状体及其细分壳核和尾核/伏核的绝对神经元数量，以及绝对胶质细胞数量和计算的胶质细胞指数。我们发现右侧精神分裂症组的绝对纹状体神经元数量显着增加（P = 0.008**），而左侧的绝对纹状体神经元数量只有更高的趋势。在进一步的分析中，精神分裂症组右侧纹状体中绝对纹状体神经元数量的显着增加仅在尾核/伏隔核复合体中可见（P = 0.01*），而在壳核中则不然。两组之间的绝对纹状体胶质细胞数量没有显着差异，无论是在右侧还是左侧。只有两侧神经胶质指数有较小的趋势。皮质发育障碍以及发育过程中自然发生的细胞死亡的连续减少可能是精神分裂症患者纹状体神经元绝对数量增加的原因。 (C) 1997 爱思唯尔科学爱尔兰有限公司
In neuropathological studies of schizophrenia, alterations of the basal ganglia are one main topic. Using the optical dissector, we performed an unbiased estimation of neurons and glia cells in the human striatum. To rule out an influence of age and gender, the brains of 9 male schizophrenic patients younger than 65 were closely matched in age with the brains of 9 male control persons. Absolute neuron numbers of the striatum and its subdivisions putamen and nucleus caudatus/nucleus accumbens of both hemispheres were compared between both groups, as were absolute glia cell numbers and the calculated glia index. We found a significant increase of absolute striatal neuron numbers in the schizophrenic group on the right side (P = 0.008**) and only a trend to higher absolute striatal neuron numbers on the left side. In a further analysis, the significant increase of absolute striatal neuron numbers in the right striatum of the schizophrenic group was only discernible for the nucleus caudatus/nucleus accumbens complex (P = 0.01*) and not for the putamen. Absolute striatal glia cell numbers did not differ significantly between both groups, neither on the right nor on the left side. There was only a trend towards a smaller glia index on both sides. Cortical developmental disturbances with a consecutive reduction of naturally occurring cell death during development could be responsible for this increase in absolute striatal neuron numbers in schizophrenics. (C) 1997 Elsevier Science Ireland Ltd.