Interictal quantitative EEG in migraine: a blinded controlled study
Interictal quantitative EEG in migraine: a blinded controlled study
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DOI：
10.1007/s10194-009-0140-4
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发表时间：
2009-10-01
影响因子：
7.4
通讯作者：
Sand, Trond
中科院分区：
文献类型：
--
作者：
Bjork, Marte Helene;Stovner, Lars J.;Sand, Trond
几项研究报告了偏头痛患者的异常脑电(EEG)。然而，很少有人评估偏头痛患者在上一次发作或下一次发作可能与结果相互作用的一段时间内的脑电结果。因此，我们将偏头痛患者和无头痛受试者的发作间期脑电与发作前改变控制干扰的设计进行了比较。在登记后的下一次发作期间，发作期前头痛侧的脑电结果也被调查了。临床变量和EEG之间的相关性也被报道。对33例偏头痛患者(6例有先兆，27例无先兆)和31例对照组的发作间期脑电进行了比较。对顶枕区、颞区和额中央区的Delta、theta和α频段的绝对功率、不对称性和相对功率进行了研究。EEG变量与发作频率、头痛持续时间、发作持续时间、疼痛强度、照片恐惧症和恐音症相关。与对照组相比，偏头痛患者在所有皮质区域的相对theta能力增加，在疼痛的额叶-中央区域的三角洲活动增加。不同组间的绝对功率和不对称性相似。在年龄调整的分析中，头痛强度与增量活动增加相关。在这项盲目对照研究中，我们发现偏头痛患者的相对theta活动在全球范围内都有所增加。发作之间可能存在轻微的发作间歇性脑功能障碍。
Abnormal electroencephalography (EEG) in migraineurs has been reported in several studies. However, few have evaluated EEG findings in migraineurs during a time period when neither the last attack nor the next attack may interact with the results. We, therefore, compared interictal EEG in migraineurs and headache-free subjects with a design controlled for interference by pre-ictal changes. Pre-ictal EEG findings in the painful cranial side during the next attack after registration were also investigated. Correlations between clinical variables and EEG are reported as well. Interictal EEGs from 33 migraineurs (6 with and 27 without aura) and 31 controls were compared. Absolute power, asymmetry and relative power were studied for delta, theta and alpha frequency bands in parieto-occipital, temporal and fronto-central areas. EEG variables were correlated to attack frequency, headache duration, attack duration, pain intensity, photo- and phonophobia. Compared with controls, migraineurs had increased relative theta power in all cortical regions and increased delta activity in the painful fronto-central region. Absolute power and asymmetry were similar among groups. In age-adjusted analyses, headache intensity correlated with increased delta activity. In this blinded controlled study, we found globally increased relative theta activity in migraineurs. A slight interictal brain dysfunction is probably present between attacks.