Unexpectedly High Prevalence of Coronary Spastic Angina in Patients With Anderson-Fabry Disease
Unexpectedly High Prevalence of Coronary Spastic Angina in Patients With Anderson-Fabry Disease
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DOI：
10.1253/circj.cj-18-0734
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发表时间：
2019-02-01
影响因子：
3.3
通讯作者：
Hasebe, Naoyuki
中科院分区：
文献类型：
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作者：
Kitani, Yuya;Nakagawa, Naoki;Hasebe, Naoyuki
工作背景：虽然我们和其他人报道的情况下，安德森-法布里病（AFD）并发冠状动脉痉挛性心绞痛（CSA），CSA在这些patients的患病率仍然unknown.Methods和Results：我们进行了乙酰胆碱诱导的激发试验，根据日本指南的诊断和治疗CSA患者，在9例连续5个独立的AFD家系。冠状动脉痉挛引起的症状和心电图缺血性变化，在8 9例（89%）AFD.Conclusions：我们发现了一个意想不到的高患病率CSA AFD患者。
Background: Although we and others have reported cases of patients with Anderson-Fabry disease (AFD) complicated by coronary spastic angina (CSA), the prevalence of CSA in these patients remains unknown.Methods and Results: We performed the acetylcholine-induced provocation test, according to the Japanese guidelines for the diagnosis and treatment of patients with CSA, in 9 consecutive patients having 5 independent AFD pedigrees. Coronary spasms were provoked in conjunction with symptoms and ECG ischemic changes in 8 of 9 (89%) patients with AFD.Conclusions: We found an unexpectedly high prevalence of CSA in patients with AFD.