Perceived intensity of somatosensory cortical electrical stimulation.

Perceived intensity of somatosensory cortical electrical stimulation.
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DOI:
10.1007/s00221-010-2254-y
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发表时间:
2010-06
影响因子:
2
通讯作者:
Judy, Jack W.
Judy, Jack W.
中科院分区:
医学4区
文献类型:
--
作者:
Fridman, Gene Y.;Blair, Hugh T.;Blaisdell, Aaron P.;Judy, Jack W.

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通过植入微电极直接刺激大脑感觉区域可以产生人工感觉,但这种人工感觉的感知心理物理学尚不清楚。基于先前在皮质刺激方面的工作,我们假设电刺激的感知强度可以通过受刺激序列影响的神经元的群体反应来解释。为了探索这一假设,我们使用泄漏神经积分器对刺激脉冲序列的感知强度进行了建模。然后,我们进行了一系列两种选择的强迫选择行为实验,在这些实验中,我们系统地测试了大鼠辨别传递到胡须桶体感皮层的电脉冲序列的频率、幅度和持续时间的能力。我们发现该模型能够预测动物的表现,支持了这样的观点:感知强度很大程度上可以通过刺激序列引起的动作电位的时空整合来解释。
Artificial sensations can be produced by direct brain stimulation of sensory areas through implanted microelectrodes, but the perceptual psychophysics of such artificial sensations are not well understood. Based on prior work in cortical stimulation, we hypothesized that perceived intensity of electrical stimulation may be explained by the population response of the neurons affected by the stimulus train. To explore this hypothesis, we modeled perceived intensity of a stimulation pulse train with a leaky neural integrator. We then conducted a series of two-alternative forced choice behavioral experiments in which we systematically tested the ability of rats to discriminate frequency, amplitude, and duration of electrical pulse trains delivered to the whisker barrel somatosensory cortex. We found that the model was able to predict the performance of the animals, supporting the notion that perceived intensity can be largely accounted for by spatiotemporal integration of the action potentials evoked by the stimulus train.
DOI: 10.3758/bf03203958
发表时间: 1974-01-01
期刊: PERCEPTION & PSYCHOPHYSICS
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LEDERMAN, SJ
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