Cholinergic modulation of hippocampal cells and circuits
Cholinergic modulation of hippocampal cells and circuits
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DOI：
10.1113/jphysiol.2004.076539
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发表时间：
2005-01-01
影响因子：
5.5
通讯作者：
Davies, CH
中科院分区：
文献类型：
--
作者：
Cobb, SR;Davies, CH
隔-海马胆碱能纤维在整个海马结构中广泛分支，在不同神经元群体差异表达的多种毒蕈碱和烟碱乙酰胆碱受体上释放乙酰胆碱。海马回路内细胞兴奋性和突触传递的调制结果是乙酰胆碱影响海马网络动态特性的能力的基础，并导致出现一系列稳定的振荡网络状态。最近的研究结果表明，许多行动有助于乙酰胆碱的促肾上腺皮质激素的性质，这主要是由激活毒蕈碱受体诱导，但也通过激活烟碱受体亚型的调节。
Septo-hippocampal cholinergic fibres ramify extensively throughout the hippocampal formation to release acetylcholine upon a diverse range of muscarinic and nicotinic acetylcholine receptors that are differentially expressed by distinct populations of neurones. The resultant modulation of cellular excitability and synaptic transmission within hippocampal circuits underlies the ability of acetylcholine to influence the dynamic properties of the hippocampal network and results in the emergence of a range of stable oscillatory network states. Recent findings suggest a multitude of actions contribute to the oscillogenic properties of acetylcholine which are principally induced by activation of muscarinic receptors but also regulated through activation of nicotinic receptor subtypes.