OncoTREAT: a software assistant for cancer therapy monitoring
OncoTREAT: a software assistant for cancer therapy monitoring
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DOI：
10.1007/s11548-006-0059-z
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发表时间：
2007-02-01
影响因子：
3
通讯作者：
Peitgen, Heinz-Otto
中科院分区：
文献类型：
--
作者：
Bornemann, Lars;Dicken, Volker;Peitgen, Heinz-Otto
目的癌症是世界范围内的主要死亡原因之一，治疗方案往往与患者的严重压力和高昂的费用有关。因此，精确的评价治疗的成功是至关重要的。材料和方法在VICORA研究项目（虚拟研究所计算机辅助临床放射学）的框架内，开发了一个软件应用程序，以支持放射科医生在评估肿瘤治疗的反应。该应用程序提供了后续支持肿瘤治疗监测的肺，肝和脑转移瘤的体积定量以及扩大的淋巴结，并协助用户通过时间登记的病变positions.Results与计算机科学家和放射科医生之间的密切合作的应用程序进行了测试和优化，以实现高度的可用性。几个临床研究进行了评估的鲁棒性和再现性的volumetry methods.Conclusion自动体积和分割允许可靠的检测肿瘤生长，并有可能增加的可靠性和意义的监测肿瘤生长在后续检查。
Object Cancer is one of the leading causes of death worldwide and therapy options are often associated with severe stress for the patient and high costs. Therefore, precise evaluation of therapy success is essential.Material and methods In the framework of the VICORA research project (Virtual Institute for Computer Assistance in Clinical Radiology), a software application was developed to support the radiologist in evaluating the response to tumor therapy. The application provides follow-up support for oncological therapy monitoring by volumetric quantification of lung, liver and brain metastases as well as enlarged lymph nodes and assists the user by temporal registration of lesion positions.Results With close cooperation between computer scientists and radiologists the application was tested and optimized to achieve a high degree of usability. Several clinical studies were carried out to evaluate the robustness and reproducibility of the volumetry methods.Conclusion Automatic volumetry and segmentation allows reliable detection of tumor growth and has the potential to increase reliability and significance of monitoring tumor growth in follow-up examinations.