A role for β-melanocyte-stimulating hormone in human body-weight regulation
A role for β-melanocyte-stimulating hormone in human body-weight regulation
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DOI：
10.1016/j.cmet.2006.01.007
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发表时间：
2006-02-01
期刊：
影响因子：
29
通讯作者：
Krude, H
中科院分区：
文献类型：
--
作者：
Biebermann, H;Castañeda, TR;Krude, H
表达阿黑皮素原（POMC）的神经元通过外周激素如瘦素、胆囊收缩素、生长激素释放肽和胰岛素介导食欲驱动的调节。大多数研究工作都集中在α-黑素细胞刺激激素（α-MSH）作为主要的POMC衍生的神经肽在人体能量平衡和体重的中央调节。在这里，我们报告错义突变的POMC衍生肽β-MSH（Y 5C-β-MSH）的编码区内，其与早发性人类肥胖症。体外和体内数据以及死后人脑研究表明，POMC衍生的神经肽β-MSH在人类下丘脑控制体重中起关键作用。
Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on alpha-melanocyte-stimulating hormone (alpha-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide beta-MSH (Y5C-beta-MSH) and its association with early-onset human obesity. In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide beta-MSH plays a critical role in the hypothalamic control of body weight in humans.