Computational insights into the role of glutathione in oxidative stress.
Computational insights into the role of glutathione in oxidative stress.
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DOI：
10.2174/1567202611310020011
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发表时间：
2013-05
影响因子：
2.1
通讯作者：
Caitlin E Presnell;Gaurav Bhatti;L. Numan;M. Lerche;Salem K Alkhateeb;M. Ghalib;M. Shammaa;M. Kavdia-M.
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文献类型：
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作者：
Caitlin E Presnell;Gaurav Bhatti;L. Numan;M. Lerche;Salem K Alkhateeb;M. Ghalib;M. Shammaa;M. Kavdia-M.
血管组织中活性氧（ROS）的产生和氧化应激与许多疾病有关。谷胱甘肽（GSH）是最丰富的低分子量非蛋白硫醇之一，可调节ROS的生理水平，并参与细胞的氧化应激反应。GSH/GSSG氧化还原偶对通常用于测量氧化应激状态。据报道，谷胱甘肽失衡存在于许多疾病状态，包括动脉粥样硬化、癌症、神经退行性疾病和衰老。谷胱甘肽在调节细胞内ROS中的重要性涉及其对氧化应激损伤作用的保护性防御和促进ROS细胞信号传导的作用。在本文中，我们回顾了基于GSH参与氧化应激的计算和数学模型的质量平衡和动力学反应的重要结果。重点是ROS和氧化应激的调解与细胞的抗氧化能力。我们讨论了谷胱甘肽在细胞氧化还原状态中的作用，通过谷胱甘肽合成、清除自由基、调节过氧化氢水平和与一氧化氮途径的相互作用来维持体内平衡。
Excess reactive oxygen species (ROS) generation and oxidative stress in vascular tissue is associated with many diseases. Glutathione (GSH), one of the most abundant low molecular weight non-protein thiols, modulates physiological levels of ROS and is involved in the cell's oxidative stress response. The GSH/GSSG redox couple is commonly used in measuring oxidative stress status. The imbalance of GSH is reported in many disease states including atherosclerosis, cancer, neurodegenerative disease, and aging. The importance of GSH in modulation of intracellular ROS involves both its protective defense against the damaging effects of oxidative stress and its role in facilitating ROS cell signaling. In this paper, we review significant results obtained from mass balance and kinetic reactions based computational and mathematical models of GSH participation in oxidative stress. The focus is on the mediation of ROS and oxidative stress with respect to the antioxidant capacity of the cell. We discuss the role of GSH in the redox state of the cell, maintaining homeostasis through GSH synthesis, scavenging of free radicals, modulating hydrogen peroxide level and interacting with nitric oxide pathways.