Topographical projections from the nucleus basalis magnocellularis (Meynert) to the frontal cortex: A voltage-sensitive dye imaging study in rats
Topographical projections from the nucleus basalis magnocellularis (Meynert) to the frontal cortex: A voltage-sensitive dye imaging study in rats
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DOI：
10.1016/j.brs.2017.06.008
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发表时间：
2017-09-01
影响因子：
7.7
通讯作者：
Takashima, Ichiro
中科院分区：
文献类型：
--
作者：
Nagasaka, Kazuaki;Watanabe, Yumiko;Takashima, Ichiro
背景：大细胞基底核/Meynert (NBM) 已被探索作为神经系统疾病的深部脑刺激的新靶点。尽管解剖学研究表明NBM存在胆碱能地形投影，但NBM亚区是否差异性激活额叶皮层仍不清楚。目的：研究NBM和额叶皮层之间的地形。方法：对大鼠NBM的前部和后部施加电刺激，并使用电压敏感染料（VSD）成像研究诱发的额叶活动。结果：VSD成像揭示了NBM的功能地形。 NBM 和额叶皮层：NBM 的前后轴对应于背侧额叶皮层的中外侧轴。结论：目前的结果表明 NBM 对额叶神经元活动进行位点特异性控制。这些发现具有实际意义，因为 NBM 的前部和后部可以分别改善认知和运动功能。 (C) 2017 Elsevier Inc. 保留所有权利。
Background: The nucleus basalis magnocellularis/Meynert (NBM) has been explored as a new target for deep brain stimulation for neurological disorders. Although anatomical studies suggest the existence of cholinergic topographical projections of the NBM, it is still unknown whether NBM subregions differentially activate the frontal cortex.Objective: To investigate the topography between the NBM and frontal cortex.Methods: Electrical stimulation was applied to the anterior and posterior sites of the NBM in rats, and the evoked frontal activity was investigated using voltage-sensitive dye (VSD) imaging.Results: VSD imaging revealed the functional topography of the NBM and frontal cortex: the anteroposterior axis of the NBM corresponded to the mediolateral axis of the dorsal frontal cortex.Conclusion: The present results suggest site-specific control of frontal neuronal activity by the NBM. These findings have practical implications, as the anterior and posterior parts of the NBM could be targeted to improve cognitive and motor function, respectively. (C) 2017 Elsevier Inc. All rights reserved.