Effect of gut microflora on nutritional availability of selenium
Effect of gut microflora on nutritional availability of selenium
复制标题
肠道菌群对硒营养利用率的影响
DOI：
10.1016/j.foodchem.2020.126537
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发表时间：
2020
期刊：
影响因子：
8.8
通讯作者：
Ogra Yasumitsu
中科院分区：
文献类型：
--
作者：
Takahashi Kazuaki;Suzuki Noriyuki;Ogra Yasumitsu
由于硒 (Se) 是一种必需矿物质，因此动物必须能够代谢肉、鱼和蔬菜中的各种硒化合物。目前尚不清楚包括人类在内的动物如何有效地利用硒化合物，但我们假设肠道微生物群可能有助于这些过程。在这项研究中，我们发现硒甲基硒代半胱氨酸和硒氰酸盐被肠道微生物代谢为硒代蛋氨酸（SeMet），这表明硒化合物可能代谢为SeMet，从而被宿主生物利用。尿液中主要的硒糖，即 1β-甲基硒代-N-乙酰基-d-半乳糖胺，在微生物群受到抑制的大鼠中的利用量低于健康大鼠，这表明这种糖可以通过具有健康微生物群的动物的肠道微生物群转化为营养可用的形式。我们的结论是，至少在大鼠中，肠道微生物群在宿主动物的硒代谢中发挥作用，这一发现可能值得在人类中进行研究。
Since selenium (Se) is an essential mineral, animals must be able to metabolize the various selenocompounds in meat, fish and vegetables. It is unclear how animals, including humans, utilize selenocompound efficiently, but we hypothesized that gut microflora might contribute to these processes. In this study, we revealed that Se-methylselenocysteine and selenocyanate were metabolized to selenomethionine (SeMet) by intestinal microflora, suggesting selenocompounds might be metabolized to SeMet, which can be used by the host organism. The major urinary selenosugar, 1β-methylseleno-N-acetyl-d-galactosamine, was utilized less in microflora-suppressed than healthy rats, suggesting that this sugar can be transformed to a nutritionally available form by gut microflora in animals with a healthy microbiota. We concluded that, in rats at least, gut microflora has a role in the metabolism of Se in the host animal, and this finding might be worth investigating in humans.