Enhanced estrogen-induced proliferation in obese rat endometrium
Enhanced estrogen-induced proliferation in obese rat endometrium
复制标题
DOI：
10.1016/j.ajog.2008.08.064
复制
发表时间：
2009-02-01
影响因子：
9.8
通讯作者：
Lu, Karen H.
中科院分区：
文献类型：
--
作者：
Zhang, Qian;Shen, Qi;Lu, Karen H.
目的：研究设计：使用Zucker fa/fa肥胖大鼠和瘦对照，我们检测了雌二醇短期治疗后子宫内膜细胞增殖和某些雌激素调节的促增殖和抗增殖基因的表达模式。在肥胖大鼠和瘦大鼠之间未观察到显著的形态学/组织学差异。雌激素诱导的促增殖基因cyclin A和c-Myc mRNA的表达显着高于肥胖大鼠的子宫内膜与那些瘦对照组。抗增殖基因p27 Kip 1的表达被抑制的雌激素治疗肥胖和瘦大鼠，但是，减少肥胖大鼠更为明显。雌激素更强烈地诱导抗增殖基因视黄醇脱氢酶2和分泌frizzled相关蛋白4在瘦大鼠，但在肥胖rates.CONCLUSION：增强雌激素诱导的子宫内膜促增殖基因的表达和抑制抗增殖基因的表达被认为是在肥胖与瘦动物的子宫内膜。
OBJECTIVE: We tested the hypothesis that the proliferative estrogen effect on the endometrium is enhanced in obese vs lean animals.STUDY DESIGN: Using Zucker fa/fa obese rats and lean control, we examined endometrial cell proliferation and the expression patterns of certain estrogen-regulated proproliferative and antiproliferative genes after short-term treatment with estradiol.RESULTS: No significant morphologic/histologic difference was seen between the obese rats and the lean rats. Estrogen-induced proproliferative genes cyclin A and c-Myc messenger RNA expression were significantly higher in the endometrium of obese rats compared with those of the lean control. Expression of the antiproliferative gene p27Kip1 was suppressed by estrogen treatment in both obese and lean rats; however, the decrease was more pronounced in obese rats. Estrogen more strongly induced the antiproliferative genes retinaldehyde dehydrogenases 2 and secreted frizzled-related protein 4 in lean rats but had little or no effect in obese rats.CONCLUSION: Enhancement of estrogen-induced endometrial proproliferative gene expression and suppression of antiproliferative gene expression was seen in the endometrium of obese vs lean animals.