Visualization and quantification of breast cancer biomechanical properties with magnetic resonance elastography
Visualization and quantification of breast cancer biomechanical properties with magnetic resonance elastography
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DOI：
10.1088/0031-9155/45/6/314
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发表时间：
2000-06-01
影响因子：
3.5
通讯作者：
Sciarretta, J
中科院分区：
文献类型：
--
作者：
Plewes, DB;Bishop, J;Sciarretta, J
提出了一种评价乳腺癌的准静态磁共振弹性成像(MRE)方法。采用位相对比、刺激回波磁共振成像方法，对体模和志愿者进行了应变成像。概述和演示了基于逆应变映射的组织生物力学特性的一阶评估。通过在二维模型和拟人化的三维乳腺有限元模型中的模拟，研究了逆应变成像的准确性。为了提高弹性成像评估弹性模量的精度，讨论了作为应变成像的扩展的反演方法，并根据稳健反演所需的位移信号/噪声来模拟量化MRE。描述了一种提供关于组织模数和压力分布的信息的直接反转策略以及一种利用组织几何先验知识的新型迭代方法。结果表明，通过明智地选择先前增强的MRI乳腺图像的信息，可以显著降低对MRE数据的采集要求，同时在存在应变噪声的情况下保持稳健的模数重建。介绍了一种临床乳腺磁共振成像的实验装置和一个正常志愿者的初步图像。
A quasistatic magnetic resonance elastography (MRE) method for the evaluation of breast cancer is proposed. Using a phase contrast, stimulated echo MRI approach, strain imaging in phantoms and volunteers is presented. First-order assessment of tissue biomechanical properties based on inverse strain mapping is outlined and demonstrated. The accuracy of inverse strain imaging is studied through simulations in a two-dimensional model and in an anthropomorphic, three-dimensional finite-element model of the breast. To improve the accuracy of modulus assessment by elastography, inverse methods are discussed as an extension to strain imaging, and simulations quantify MRE in terms of displacement signal/noise required for robust inversion. A direct inversion strategy providing information on tissue modulus and pressure distribution is described along with a novel iterative method utilizing a priori knowledge of tissue geometry. It is shown that through the judicious choice of information from previous contrast-enhanced MRI breast images, MRE data acquisition requirements can be significantly reduced while maintaining robust modulus reconstruction in the presence of strain noise. An experimental apparatus for clinical breast MRE and preliminary images of a normal volunteer are presented.