Prevalence of spontaneous Brugada ECG pattern recorded at standard intercostal leads: A meta-analysis
Prevalence of spontaneous Brugada ECG pattern recorded at standard intercostal leads: A meta-analysis
复制标题
标准肋间导联记录的自发 Brugada 心电图模式的患病率：荟萃分析
DOI：
10.1016/j.ijcard.2017.11.113
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发表时间：
2018-03-01
影响因子：
3.5
通讯作者：
Hu, Dan
中科院分区：
文献类型：
--
作者：
Shi, Shaobo;Barajas-Martinez, Hector;Hu, Dan
目的：典型的Brugada心电图型是Brugada综合征诊断的重点。然而，确切的流行率仍不清楚，特别是在亚洲。本研究旨在系统评价标准导联记录的自发性Brugada心电图样的患病率。方法：检索Medline、Embase和中国国家知识基础设施(CNKI)2003年1月1日至2016年9月1日收录的Brugada心电图样的患病率研究。在随机效应模型中估计1型和2型-3型Brugada心电模式的混合患病率，并根据研究的特点估计群体患病率数据。结果：共筛选出39篇符合条件的研究，涉及558,689名受试者。1型和2-3型Brugada心动图的合并患病率分别为0.03%(95%CI，0.01%~0.06%)和0.42%(95%CI，0.28%~0.59%)。地区、样本量、发表年份是异质性的主要来源。男性、亚洲人、成人、病人和发热者中，1型Brugada心电图型的患病率较高，而发热与2-3型Brugada心电图型的关系不明显。敏感性分析显示，各研究并不单独影响1型和2型-3型Brugada心电图型的患病率。结论：Brugada心电图型并不罕见，尤其在亚洲成年男性和发热者中占优势。需要重视潜在人群中Brugada综合征的临床筛查和进一步检查。(C)2017爱思唯尔B.V.保留所有权利。
Objective: Typical Brugada ECG pattern is the keystone in the diagnosis of Brugada syndrome. However, the exact prevalence remains unclear, especially in Asia. The present study was designed to systematically evaluate the prevalence of spontaneous Brugada ECG pattern recorded at standard leads.Methods: We searched the Medline, Embase and Chinese National Knowledge Infrastructure (CNKI) for studies of the prevalence of Brugada ECG pattern, published between Jan 1, 2003, and September 1, 2016. Pooled prevalence of type 1 and type 2-3 Brugada ECG pattern were estimated in a random-effects model, and group prevalence data by the characteristic of studies. Meta-regression analyses were performed to explore the potential sources of heterogeneity, and sensitivity analyses were conducted to assess the effect of each study on the overall prevalence.Results: Thirty-nine eligible studies involving 558,689 subjects were identified. Pooled prevalence of type 1 and 2-3 Brugada ECG pattern was 0.03% (95% CI, 0.01%-0.06%), and 0.42% (95% CI, 0.28%-0.59%), respectively. Regions, sample size, year of publication were the main source of heterogeneity. The prevalence of type 1 Brugada ECG pattern was higher in male, Asia, adult, patient, and fever subjects; but the relation between fever and type 2-3 Brugada ECG pattern was not significant. Sensitivity analysis showed that each study did not lonely affect the prevalence of type 1 and type 2-3 Brugada ECG pattern.Conclusion: Brugada ECG pattern is not rare, especially preponderant in adult Asian males, and fever subjects. Clinical screening and further examination of Brugada syndrome in potential population need to be highlighted. (C) 2017 Elsevier B.V. All rights reserved.