Diabetes mellitus, anti-secretory drugs and other risk factors for Campylobacter gastro-enteritis in adults: a case-control study
Diabetes mellitus, anti-secretory drugs and other risk factors for Campylobacter gastro-enteritis in adults: a case-control study
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DOI：
10.1017/s0950268897008224
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发表时间：
1997-12-01
影响因子：
4.2
通讯作者：
Slack, RCB
中科院分区：
文献类型：
--
作者：
Neal, KR;Slack, RCB
采用病例对照研究和邮寄问卷调查的方法，对诺丁汉卫生区成人弯曲杆菌胃肠炎报告病例的流行病学进行了调查，以确定危险因素的数据。在14个月的时间里，531例（所有实验室确诊病例的73%应答率）和512例对照者进行了应答。其中包括国外旅行（OR = 3.4; 95%置信区间（CT）2.0-5.7），糖尿病（OR 4.1，CI 1.1-17），与奥美拉唑联合用药（OR 3.5，CI 1.1-12）和H-2和H-2拮抗剂（OR 3.7，CI 1.3-15），与幼犬接触（OR 11.3，CI 1.2-105），吃鸡肉（OR 1.4，CI 1.1-1.8）和喝顶部被鸟损坏的瓶子里的牛奶（OR 3.3，CI 1.0-11）。准备主餐（OR 0.9，CI 0.8-1.0）和饮用外送牛奶（OR 0.6，CI 0.4-0.9）与弯曲杆菌感染风险降低相关。25%的病例报告了国外旅行，另有15%与其他风险因素显著相关。大多数病例（60%）仍然无法解释，表明散发病例需要进一步演变。
The epidemiology of notified cases of campylobacter gastroenteritis in adults in Nottingham Health District was investigated using a case-control study with a postal questionnaire to ascertain data on risk factors. Over a 14-month period 531 cases (a 73% response rate of all laboratory confirmed cases) and 512 controls replied.Conditional logistic regression analysis was used to determine independent associations with infection. These included foreign travel (odds ratio (OR) 3.4; 95% confidence intervals (CT) 2.0-5.7), diabetes mellitus (OR 4.1, CI 1.1-17), medication with omeprazole (OR 3.5, CI 1.1-12) and H-2 and H-2 antagonists (OR 3.7, CI 1.3-15), contact with puppies (OR 11.3, CI 1.2-105), eating chicken (OR 1.4, CI 1.1-1.8) and drinking milk from bottles with tops damaged by a bird (OR 3.3, CI 1.0-11). Preparing main meals (OR 0.9, CI 0.8-1.0) and drinking delivered milk (OR 0.6, CI 0.4-0.9) were associated with a reduced risk of campylobacter infection.Foreign travel was reported in 25% of cases and another 15% had significant associations with other risk factors. The majority of cases, 60%, remained unexplained, indicating the need for further evolution of sporadic cases.