Sperm protein 17 is expressed in human somatic ciliated epithelia
Sperm protein 17 is expressed in human somatic ciliated epithelia
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DOI：
10.1177/002215540405200414
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发表时间：
2004-04-01
影响因子：
3.2
通讯作者：
Kast, WM
中科院分区：
文献类型：
--
作者：
Grizzi, F;Chiriva-Internati, M;Kast, WM
人们曾经认为精子蛋白 17 (Sp17) 仅在睾丸中表达，其唯一功能是在受精过程中与卵母细胞结合。然而，人类呼吸道和生殖系统的免疫组织化学表明，它在纤毛细胞中含量丰富，但在具有静纤毛和微绒毛的人类细胞中并不丰富。整个 N 端半部的高度序列保守性，以及该区域内 A 激酶锚定蛋白 (AKAP) 结合基序的存在，表明 Sp17 在雄性生殖细胞和纤毛体细胞中的 PKA 缺失的 AKAP 复合体中发挥着调节作用。
It was once believed that sperm protein 17 (Sp17) was expressed exclusively in the testis and that its sole function was to bind to the oocyte during fertilization. However, immunohistochemistry of the human respiratory airways and reproductive systems show that it is abundant in ciliated cells but not in human cells with stereocilia and microvilli. The high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP)-binding motif within this region, suggest that Sp17 plays a regulatory role in a PKA-inclepenclent AKAP complex in both male germinal and ciliated somatic cells.