DISTRIBUTION OF PRIMARY VESTIBULAR FIBERS IN THE BRAIN-STEM AND CEREBELLUM OF THE MONKEY
DISTRIBUTION OF PRIMARY VESTIBULAR FIBERS IN THE BRAIN-STEM AND CEREBELLUM OF THE MONKEY
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DOI：
10.1016/0006-8993(84)91040-0
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
CARPENTER, MB
中科院分区：
文献类型：
--
作者：
CARLETON, SC;CARPENTER, MB
试图确定神经节细胞支配的个体半规管在猴子通过植入或注射氚化氨基酸（亮氨酸和/或脯氨酸），或辣根过氧化物酶（HRP），选择性地进入一个单一的壶腹的中央投影。在接受同位素植入物或注射的动物中，通过前庭神经节的中枢转运分为三类：（1）来自神经支配迷路所有接受元件的神经节细胞的转运，（2）来自神经支配三个半圆管的神经节细胞的转运，以及（3）来自神经支配后半圆管的下前庭神经节细胞的转运。在使用脯氨酸且存活超过12天的动物中，在次级前庭纤维中观察到同位素的跨神经元转运。次级听觉纤维的Transneuronal标记是独立的[3 H]氨基酸的使用，并发生生存10天或更长时间。将HRP植入动物的外半规管壶腹，可逆行转运至前庭和耳蜗的传出神经元，但未引起初级前庭或听觉纤维的跨神经节标记，初级前庭纤维终止于前庭上级核（SVN）和前庭内侧核（MVN）。在SVN，终端是最明显的在其中央大细胞的部分，但延伸到周边部分的核，除了一个小的内侧区附近的交界处与口极的MVN。初级投射到MVN均匀分布在整个核，除了一个小的圆形区域的稀疏终末沿着其腹侧边缘。初级前庭传入主要终止于前庭下核（IVN）的吻侧和尾侧部分，但不到达细胞群“f”。投射到外侧前庭神经核（LVN）仅限于其腹侧部分。初级投射到前庭副核到达前庭神经间质核（NIVN）和细胞群“y”。纤维伸出前庭核（VN），同侧终止于副楔束核（ACN）、三叉神经下外侧网状核（SLRN）和网状结构（RF）的明确部分。投射到SVN和MVN主要来自支配半规管的神经节细胞，而投射到尾侧IVN、细胞群“y”和ACN主要与前庭神经节的黄斑部有关。NIVN接受黄斑和导管传入。后导管传入终止于SVN的内侧部分，在MVN的吻外侧部分，并在吻侧IVN。同位素Transneuronal运输增加了同侧VN的终端标签的体积，但不是在背侧LVN，或细胞群“F”或“X”。次级前庭纤维跨神经元转运的质量取决于：（1）存活时间，（2）与VN的接近程度，（3）投射的兴奋或抑制性质。初级前庭小脑纤维主要终止于同侧结节和腹侧悬雍垂。较小的突起到达小叶、第V和第VI小叶的深叶以及小舌。初级前庭小脑投射终止于这些皮质区颗粒层的苔藓纤维突起。初级前庭纤维没有终止于灵长类动物的顶核。
Attempts were made to determine the central projections of ganglion cells innervating individual semicircular ducts in the monkey by implanting or injecting tritiated amino acids (leucine and/or proline), or horseradish peroxidase (HRP), selectively into a single ampulla. Central transport via the vestibular ganglion in animals receiving isotope implants or injections fell into three categories: (1) transport from ganglion cells innervating all receptive elements of the labyrinth, (2) transport from ganglion cells innervating the three semicircular ducts, and (3) transport from cells of the inferior vestibular ganglion innervating the posterior semicircular duct. Transneuronal transport of isotope was observed in secondary vestibular fibers in animals where proline was used and survival exceeded 12 days. Transneuronal labeling of secondary auditory fibers was independent of the [3H]amino acid used, and occurred with survivals of 10 or more days. HRP implanted into the ampulla of the lateral semicircular duct in several animals produced retrograde transport to efferent vestibular and cochlear neurons, but did not result in transganglionic labeling of primary vestibular or auditory fibers.Primary vestibular fibers terminate throughout the superior (SVN) and medial vestibular nuclei (MVN). Within SVN, terminals are most pronounced in its central large-celled portion, but extend into peripheral parts of the nucleus, except for a small medial area near its junction with the oral pole of MVN. Primary projections to MVN are homogenously distributed throughout the nucleus excepting a small circular area of sparse terminals along its ventral margin. Primary vestibular afferents terminate mainly in rostral and caudal portions of the inferior vestibular nucleus (IVN), but do not reach cell group ‘f’. Projections to the lateral vestibular nucleus (LVN) are restricted to its ventral part. Primary projections to the accessory vestibular nuclei reach the interstitial nucleus of the vestibular nerve (NIVN) and cell group ‘y’. Fibers project beyond the vestibular nuclei (VN) to terminate ipsilaterally in the accessory cuneate nucleus (ACN), the subtrigeminal lateral reticular nucleus (SLRN), and well-defined portions of the reticular formation (RF). Projections to SVN and MVN are derived primarily from ganglion cells innervating the semicircular ducts, while projections to caudal IVN, cell group ‘y’ and ACN are related mainly to macular portions of the vestibular ganglion. NIVN receives both macular and duct afferents. Posterior duct afferents terminate in medial portions of SVN, in rostrolateral portions of MVN, and in rostral IVN.Transneuronal transport of isotope increases the volume of terminal label in the ipsilateral VN, but not in dorsal LVN, or cell groups ‘f’ or ‘x’. The quality of transneuronal transport in secondary vestibular fibers is dependent upon: (1) survival time, (2) proximity to the VN, and (3) the excitatory or inhibitory nature of the projection.Primary vestibulocerebellar fibers terminate heavily in the ipsilateral nodulus and ventral uvula. Lesser projections reach the flocculus, deep folia of vermal lobules V and VI, and the lingula. Primary vestibulocerebellar projections terminate as mossy fiber rosettes in the granular layer of these cortical areas. No primary vestibular fibers terminate in the primate fastigial nuclei.