Conformational changes associated with protein-protein interactions
Conformational changes associated with protein-protein interactions
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DOI：
10.1016/j.sbi.2004.01.005
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发表时间：
2004-02-01
影响因子：
6.8
通讯作者：
Gerstein, M
中科院分区：
文献类型：
--
作者：
Goh, CS;Milburn, D;Gerstein, M
与蛋白质-蛋白质结合事件相关的运动可以从大分子运动数据库的角度进行调查。有许多替代的概念模型来描述这些事件，特别是诱导拟合和预先存在的平衡。最近对构象变化的研究都有证据支持这两种选择。然而，越来越多的人支持预先存在的平衡模型，即发现蛋白质同时存在于不同构象的群体中。
Motions related to protein-protein binding events can be surveyed from the perspective of the Database of Macromolecular Movements. There are a number of alternative conceptual models that describe these events, particularly induced fit and pre-existing equilibrium. There is evidence for both alternatives from recent studies of conformational change. However, there is increasing support for the pre-existing equilibrium model, whereby proteins are found to simultaneously exist in populations of diverse conformations.