Infection due to Penicillium marneffei, an emerging pathogen: Review of 155 reported cases
Infection due to Penicillium marneffei, an emerging pathogen: Review of 155 reported cases
复制标题
DOI：
10.1093/clinids/23.1.125
复制
发表时间：
1996-07-01
影响因子：
11.8
通讯作者：
Duong, TA
中科院分区：
文献类型：
--
作者：
Duong, TA
马尔尼菲青霉病是一种播散性和进行性感染，是东南亚某些地区人类免疫缺陷病毒（HIV）感染患者的第三大常见机会性感染。马尔尼菲青霉菌是东南亚和中国南部的地方病。东方和西方国家都报告了病例。本文就155例马尔尼菲青霉病的病史、流行病学、真菌学、临床表现、诊断和治疗作一综述。大约80%的患者免疫功能低下。马尔尼菲青霉可以感染各种器官，特别是肺、肝和皮肤。最常见的临床特征包括发热、体重减轻和贫血。这种微生物最常见的是从皮肤、血液和骨髓中分离出来。真菌分离株的免疫学鉴定可以用外抗原试验和免疫组织化学方法进行。肠外应用阿替霉素B和伊曲康唑治疗HN感染的播散性马尔尼菲青霉病是相对有效和安全的。
A disseminated and progressive infection, penicilliosis marneffei is the third most common opportunistic infection in human immunodeficiency virus (HIV)-infected patients in certain parts of Southeast Asia. Penicillium marneffei is endemic in Southeast Asia and the southern part of China. Cases have been reported from both Eastern and Western countries. This review discusses the history, epidemiology, mycology, clinical manifestations, diagnosis, and treatment of penicilliosis marneffei, on the basis of 155 cases of the infection. About 80% of the patients are immunocompromised. P. marneffei can infect various organs, particularly the lung, liver, and skin. The most common clinical features include fever, weight loss, and anemia. The organism has been isolated most commonly from skin, blood, and bone marrow. Immunologic identification of fungal isolates can be done with exoantigen tests and immunohistochemical methods. Treatment of disseminated penicilliosis marneffei in HN-infected patients with parenteral amphotericin B and itraconazole is relatively effective and safe.