Abnormal cerebellum-DMN regions connectivity in unmedicated bipolar II disorder
Abnormal cerebellum-DMN regions connectivity in unmedicated bipolar II disorder
复制标题
未接受药物治疗的 II 型双相情感障碍中小脑-DMN 区域连接异常
DOI：
10.1016/j.jad.2018.09.076
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发表时间：
2019-01-15
影响因子：
6.6
通讯作者：
Wang, Ying
中科院分区：
文献类型：
--
作者：
Chen, Guanmao;Zhao, Lianping;Wang, Ying
目的：双相情感障碍（BD）是一种常见的精神疾病。先前的研究发现BD患者的结构和功能性脑连接异常。然而，很少有研究集中在BD患者小脑及其亚区域的功能连接（FC）。本研究旨在研究BD II患者小脑默认模式网络（DMN）区域的FC。方法：90例未经药物治疗的BD II抑郁症患者和100例健康对照者（HC）进行静息态功能磁共振成像。我们选择了三对与DMN相关的小脑亚区（双侧脚I、脚II和小叶IX）作为种子区域，并计算每个子区域的全脑FC。与HC相比，BD Ⅱ型抑郁症患者右侧第一脚与双侧楔前叶的连接增强，左侧第二脚与双侧内侧前额叶皮质的连接减弱左侧第二脚和右侧额内侧回之间。BD II抑郁组和HCs组之间的左侧小腿I和双侧小叶IX的整个FC没有显著差异。局限性：本研究是横断面的，并且没有检查来自正常胸腺BD patients.Conclusions的数据：研究结果显示BD小脑DMN区域的FC受损;在I脚和楔前叶之间以及II脚和前额叶皮质之间的部分FC表明异常小脑DMN区域FC在BD的病理生理学中的重要性。
Objective: Bipolar disorder (BD) is a common psychiatric disease. Previous studies have found abnormalities in structural and functional brain connectivity in BD patients. However, few studies have focused on the functional connectivity (FC) of the cerebellum and its sub-regions in patients with BD. The present study aimed to examine the FC of cerebellum-default mode network (DMN) regions in patients with BD II.Method: Ninety patients with unmedicated BD II depression and 100 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging. We selected three pairs of subregions of the cerebellum that are DMN-related (the bilateral Crus I, Crus II, and lobule IX) as seed regions and calculated the whole brain FC for each subregion.Results: Compared with the HCs, the patients with BD II depression showed increased connectivity between the right Crus I and bilateral precuneus and decreased connectivity between the left Crus II and bilateral medial prefrontal cortex (mPFC) and between the left Crus II and right medial frontal gyrus (MFG). There was no significant difference in the whole FC of the left Crus I and bilateral lobule IX between the BD II depression group and the HCs group.Limitations: This study was cross-sectional and did not examine data from euthymic BD patients.Conclusions: The findings showed impaired FC of cerebellum-DMN regions in BD; partial FC between the Crus I and precuneus and the Crus II and prefrontal cortex suggests the importance of abnormal cerebellum-DMN regions FC in the pathophysiology of BD.