Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma)
Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma)
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DOI：
10.1093/bja/aer229
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发表时间：
2011-11-01
影响因子：
9.8
通讯作者：
Gillespie, R. S.
中科院分区：
文献类型：
--
作者：
James, M. F. M.;Michell, W. L.;Gillespie, R. S.
背景液体在创伤复苏中的作用是有争议的。我们比较了在严重创伤中使用0.9%生理盐水与羟乙基淀粉（HES 130/0.4）复苏在复苏、液体量、胃肠道恢复、肾功能和血液制品需求方面的差异。对严重创伤患者进行的随机、对照、双盲研究。3升液体复苏。钝伤和穿透伤分别随机分组。术后随访30 d。共有115例患者接受随机化，其中109例接受了研究。对于穿透性创伤患者（n=67），HES组的平均（SD）液体需求量为5.1（2.7）升，生理盐水组为7.4（4.3）升（P
Background. The role of fluids in trauma resuscitation is controversial. We compared resuscitation with 0.9% saline vs hydroxyethyl starch, HES 130/0.4, in severe trauma with respect to resuscitation, fluid volume, gastrointestinal recovery, renal function, and blood product requirements.Methods. Randomized, controlled, double-blind study of severely injured patients requiring. 3 litres of fluid resuscitation. Blunt and penetrating trauma were randomized separately. Patients were followed up for 30 days.Results. A total of 115 patients were randomized; of which, 109 were studied. For patients with penetrating trauma (n=67), the mean (SD) fluid requirements were 5.1 (2.7) litres in the HES group and 7.4 (4.3) litres in the saline group (P