One neuron--multiple receptors: increased complexity in olfactory coding?
One neuron--multiple receptors: increased complexity in olfactory coding?
复制标题
一个神经元——多个受体：嗅觉编码的复杂性增加？
DOI：
10.1126/stke.2852005pe25
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Leinders-Zufall,Trese
中科院分区：
文献类型：
--
作者：
Spehr,Marc;Leinders-Zufall,Trese
Olfaction—the sense of smell—is responsible for detecting molecules of immense structural variety. Precise recognition of such diverse stimuli requires a massive receptor repertoire. This functional challenge has been met by simultaneous expression of a multitude of odor-detecting receptors that all belong to the superfamily of heterotrimeric GTP-binding protein (G protein)–coupled receptors. Studies conducted over the past decade have led to the assumption that an individual olfactory sensory neuron expresses only a single odorant receptor, consequently giving rise to the "one receptor–one neuron" hypothesis. This idea is attractive because of its simplicity and has served as the basis for models of olfactory coding. However, recent reports regardingDrosophilahave found exceptions to the rule that could have important implications for the logic of olfactory coding.
