Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease.
Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease.
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DOI：
10.1016/0959-4388(91)90067-h
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发表时间：
1991-10-01
影响因子：
5.7
通讯作者：
Price, D L
中科院分区：
文献类型：
--
作者：
Goedert, M;Sisodia, S S;Price, D L
阿尔茨海默氏病的特征在于在新皮层、海马和杏仁核中存在大量神经元缠结和β-淀粉样蛋白沉积。缠结和斑块的主要蛋白质组分最近已被鉴定。这些研究结果，简要回顾这里，将使研究人员设计调查，这将导致对疾病的发病机制的理解，并开发新的治疗方法，可能会导致一个有效的治疗。
Alzheimer's disease is characterized by the presence of abundant neurofibrillary tangles and beta-amyloid deposits in neocortex, hippocampus and amygdala. The major protein components of tangles and plaques have recently been identified. These findings, briefly reviewed here, will allow researchers to design investigations that will lead to an understanding of the pathogenesis of the disease and to the development of new therapeutic approaches that may result in an effective treatment.