High-Dose Glucocorticoids Inhibit Proliferation of Rat Olfactory Epithelium
High-Dose Glucocorticoids Inhibit Proliferation of Rat Olfactory Epithelium
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高剂量糖皮质激素抑制大鼠嗅上皮增殖
DOI：
10.1177/000348940211101008
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
K. Ichimura
中科院分区：
文献类型：
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作者：
Y. Ohta;Nobuko Marino;Minako Takanosawa;Shinichi Ishimoto;Chiori Matumoto;K. Ichimura
糖皮质激素（GC）通常用于治疗嗅觉功能障碍。然而，GC对嗅觉上皮的影响尚不清楚。我们研究了高剂量GC对嗅上皮细胞增殖的影响。5只成年雄性大鼠（300 g）接受单次每日皮下给药的含有0.3 mg地塞米松（DEX）的溶媒，持续9天（DEX+组），对照组仅接受溶媒（DEX-组）。我们比较了两组的Ki 67阳性细胞数量。DEX+组每500个嗅上皮细胞中Ki 67阳性细胞的平均数量为9.6，DEX-组为58（显著差异）。我们的结论是，高剂量GC抑制嗅上皮细胞的增殖。我们认为，高剂量GC抑制细胞因子和生长因子，导致继发性抑制增殖能力。
Glucocorticoids (GCs) are commonly prescribed for treatment of olfactory dysfunction. However, the effects of GCs on olfactory epithelium are not well known. We investigated the effects of high-dose GCs on proliferating cells of olfactory epithelium. Five adult male rats (300 g) received a single daily subcutaneous dose of vehicle containing 0.3 mg dexamethasone (DEX) for 9 days (DEX+ group), and a control group received vehicle alone (DEX– group). We compared sections from the Two groups for numbers of Ki67-positive cells. The mean number of Ki67-positive cells per 500 olfactory epithelial cells was 9.6 for the DEX+ group and 58 for the DEX– group (significant difference). We conclude that high-dose GC suppressed proliferation of olfactory epithelium. We suggest that high-dose GC suppresses cytokines and growth factors, resulting in secondary suppression of proliferating ability.