Iron-catalyzed chemoselective ortho arylation of aryl imines by directed C-H bond activation.
Iron-catalyzed chemoselective ortho arylation of aryl imines by directed C-H bond activation.
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DOI：
10.1002/anie.200900454
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发表时间：
2009-04
影响因子：
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通讯作者：
N. Yoshikai;A. Matsumoto;Jakob Norinder;E. Nakamura
中科院分区：
文献类型：
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作者：
N. Yoshikai;A. Matsumoto;Jakob Norinder;E. Nakamura
无Fe-ar：铁催化亚胺导向的C-H键活化以使用二芳基锌试剂将邻芳基引入苯乙酮衍生的亚胺（参见方案），而钯催化常规的取代反应。标题反应的特点是温和的和选择性的C-H键活化的芳基溴，氯，或磺酸酯基团的存在下，和1，2-二氯异丁烷是必不可少的，以实现这种选择性。
No Fe-ar: Iron catalyzes an imine-directed C-H bond activation to introduce an ortho-aryl group to an acetophenone-derived imine using a diarylzinc reagent (see scheme), whereas palladium catalyzes the conventional substitution reaction . The title reaction features mild and selective C-H bond activation in the presence of aryl bromide, chloride, or sulfonate groups, and 1,2-dichloroisobutane is essential to achieve such selectivity.