Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats
Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats
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DOI：
10.1006/exnr.2000.7506
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发表时间：
2000-12-01
影响因子：
5.3
通讯作者：
Borlongan, CV
中科院分区：
文献类型：
--
作者：
Chang, CF;Niu, KC;Borlongan, CV
高压氧（HBO）治疗中风的疗效仍有待实验室验证。我们在这里报告，成年大鼠受到阻塞的大脑中动脉，随后暴露于高压氧（3个大气压，2 x 90分钟，间隔24小时;动物在第二次给药后不久处死）或高压（HBP; 3 atm，2 x 90 min，间隔24 h;在第二次处理后不久终止的动物）在缺血后立即或延迟60分钟后通常在再灌注2.5和24小时时表现出运动缺陷的恢复，以及与经受正常大气压的缺血动物相比，在再灌注24小时时脑梗塞减少。虽然HBO和HBP治疗都促进了有益的效果，但HBO比HBP产生了更一致的保护作用。再灌注后立即或60分钟用HBO治疗同样产生脑梗死和运动缺陷的显着减轻。相反，HBP治疗对缺血的保护作用仅在缺血后立即给药时才能观察到，这导致梗死体积显著减少，但仅产生减少行为缺陷的趋势。目前的结果表明，HBO和HBP在一定程度上减少了缺血性脑损伤和行为功能障碍。
The efficacy of hyperbaric oxygen (HBO) therapy for treatment of stroke remains to be validated in the laboratory. We report here that adult rats subjected to occlusion of the middle cerebral artery and subsequently exposed to HBO (3 atm, 2 x 90 min at a 24-h intervals; animals terminated shortly after the second treatment) or hyperbaric pressure (HBP; 3 atm, 2 x 90 min at a 24-h interval; animals terminated shortly after the second treatment) immediately after the ischemia or after a 60-min delay generally displayed recovery from motor deficits at 2.5 and 24 h of reperfusion, as well as a reduction in cerebral infarction at 24 h of reperfusion compared to ischemic animals subjected to normal atmospheric pressure. While both HBO and HBP treatments promoted beneficial effects, HBO produced more consistent protection than HBP. Treatment with HBO immediately or 60 min after reperfusion equally produced significant attenuations of cerebral infarction and motor deficits. In contrast, protective effects of HBP treatment against ischemia were noted only when administered immediately after ischemia, which resulted in a significantly reduced infarction volume, but only produced a trend toward decreased behavioral deficits. The present results demonstrate that HBO and, to some extent, HBP reduced ischemic brain damage and behavioral dysfunctions.