A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase
A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase
复制标题
DOI：
10.1016/j.bmcl.2004.04.035
复制
发表时间：
2004-06-21
影响因子：
2.7
通讯作者：
Asami, T
中科院分区：
文献类型：
--
作者：
Han, SY;Kitahata, N;Asami, T
9-顺式-环氧类胡萝卜素双加氧酶（NCED）是脱落酸（阿坝）生物合成的关键酶，其作用是裂解9-顺式-环氧类胡萝卜素的烯键。设计并合成了几种去甲二氢愈创木酸（NDGA）类似物，并考察了它们作为NCED抑制剂的有效性。其中一个化合物（20）是该酶的抑制剂，并抑制阿坝的积累和气孔关闭，表明20应该是阿坝生物合成抑制剂。(C)2004爱思唯尔有限公司保留所有权利。
9-cis-Epoxycarotenoid dioxygenase (NCED), a key enzyme in abscisic acid (ABA) biosynthesis, cleaves the olefinic double bond of 9-cis-epoxycarotenoid. Several analogues of nordihydroguaiaretic acid (NDGA) were designed and synthesized, and their efficacy as inhibitors of NCED was examined. One of the synthesized compounds (20) was found to be an inhibitor of this enzyme, and inhibited ABA accumulation and stomatal closing, suggesting that 20 should be ABA biosynthesis inhibitor. (C) 2004 Elsevier Ltd. All rights reserved.