Nankakurine B, A new alkaloid from Lycopodium hamiltonii and revised stereostructure of nankakurine A
Nankakurine B, A new alkaloid from Lycopodium hamiltonii and revised stereostructure of nankakurine A
复制标题
DOI：
10.3987/com-06-10868
复制
发表时间：
2006-11
期刊：
影响因子：
0.6
通讯作者：
H. Morita;Y. Hirasawa;J. Kobayashi;Y. Obara;N. Nakahata;N. Kawahara;Y. Goda
中科院分区：
文献类型：
--
作者：
H. Morita;Y. Hirasawa;J. Kobayashi;Y. Obara;N. Nakahata;N. Kawahara;Y. Goda
从俱乐部苔藓Lycopodium hamiltonii中分离到一种新的石蒜碱碱nankakurine B(2)和nankakurine A(1)。利用NOESY相关性和化学转化相结合的方法对2的立体化学性质进行了研究。将1的立体结构修改为与2相同。Nankakurine A(1)诱导人星形细胞瘤细胞分泌神经营养因子。
A new Lycopodium alklaoid, nankakurine B (2), has been isolated from the club moss Lycopodium hamiltonii together with nankakurine A (1). Stereochemistry of 2 was elucidated by combination of NOESY correlations and chemical transformation. Stereostructure of 1 was revised to be the same as that of 2. Nankakurine A (1) induced secretion of neurotrophic factors from human astrocytoma cells.