TARDIVE DYSTONIA - LATE-ONSET AND PERSISTENT DYSTONIA CAUSED BY ANTI-PSYCHOTIC DRUGS
TARDIVE DYSTONIA - LATE-ONSET AND PERSISTENT DYSTONIA CAUSED BY ANTI-PSYCHOTIC DRUGS
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DOI：
10.1212/wnl.32.12.1335
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发表时间：
1982-01-01
期刊：
影响因子：
9.9
通讯作者：
ILSON, J
中科院分区：
文献类型：
--
作者：
BURKE, RE;FAHN, S;ILSON, J
抗精神病药物可引起迟发性和持续性肌张力障碍。这种肌张力障碍，迟发性肌张力障碍，与短暂的急性肌张力障碍反应和典型的迟发性运动障碍区别开来，后者是一种主要影响口腔区域的慢性障碍。报告了42例迟发性肌张力障碍患者。肌张力障碍的发病年龄为13-60岁。抗精神病药物治疗3天至11年后出现症状。年轻的患者往往有更多的全身性肌张力障碍。少数患者自发性缓解，但大多数患者肌张力障碍持续数年。治疗很少完全成功。最常见的有效药物是丁苯那嗪（68%的患者得到改善）和抗胆碱能药（39%的患者得到改善）。
Antipsychotic drugs can cause late-onset and persistent dystonia. This dystonia, tardive dystonia, is to be distinguished from acute dystonic reactions, which are transient, and from classic tardive dyskinesia, which is a choreic disorder that predominantly affects the oral region. Patients (42) with tardive dystonia are presented. The age of onset of dystonia was 13-60 yr. Symptoms began after 3 days to 11 yr of antipsychotic therapy. Younger patients tended to have more generalized dystonia. In a few patients, spontaneous remission occurred, but dystonia persisted for years in most. Therapy was rarely a complete success. The most frequently helpful medications were tetrabenazine (68% of patients improved) and anticholinergics (39% improved).