Interleukin-1 beta influences functional regeneration following nerve injury in mice through NF-kappa B signaling pathway
Interleukin-1 beta influences functional regeneration following nerve injury in mice through NF-kappa B signaling pathway
复制标题
Interleukin-1 beta 通过 NF-kappa B 信号通路影响小鼠神经损伤后的功能再生
作者：
Ruoyu Wu;Bi Chen;Xiang Jia;Yu Qiu;Mengyu Liu;Chengsheng Huang;Jie Feng;Qingkai Wu
This study focuses on investigating the role of interleukin‐1β(IL‐1β) in functional regeneration following nerve injury in mice. A microarray‐based mRNA profiling study was used to analyze the expression level of IL‐1βin peripheral nerve regeneration. Quantitative real‐time polymerase chain reaction and Western blot were applied to assess the IL‐1βexpressions of C57BL/6J‐crush and C57BL/6J‐crush+IL‐1βmice at different post‐injury time‐points after the standard sciatic nerve crush injury. The outcomes of nerve regeneration were evaluated by behavioral tests. IL‐1βwas found to be up‐regulated in peripheral nerve regeneration and significantly raised on the 3rd day and returned to normal levels on the 14th day after nerve injury. Compared with C57BL/6J‐crush+IL‐1βmice, the nerve regeneration of C57BL/6J‐crush mice was worse after nerve crush injury. IL‐1βincreased mechanical sensitivity and stimulated amplitude. IL‐1βcould benefit the recovery of sciatic nerve crush injury by facilitating nerve regeneration.
