TRIAL SEQUENCE OF CHANGED UNIT-ACTIVITY IN AUDITORY-SYSTEM OF ALERT RAT DURING CONDITIONED-RESPONSE ACQUISITION AND EXTINCTION
TRIAL SEQUENCE OF CHANGED UNIT-ACTIVITY IN AUDITORY-SYSTEM OF ALERT RAT DURING CONDITIONED-RESPONSE ACQUISITION AND EXTINCTION
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DOI：
10.1152/jn.1976.39.2.266
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发表时间：
1976-01-01
影响因子：
2.5
通讯作者：
STUART, DK
中科院分区：
文献类型：
--
作者：
DISTERHOFT, JF;STUART, DK
1. 在音调信号、食欲经典条件反应的获得和消失过程中，研究了警觉、自由活动的大鼠听觉系统中单元的活动。在 10 个试验组中，对 74 只大鼠进行了下丘 (N = 28)、内侧膝状体 (N = 32)、丘脑后核 (N = 28)、顶盖前区 (N = 19) 和皮质 (N = 100) 神经元反应的研究。 2. 在行为习得过程中，丘脑后核的神经元首先表现出对 CS+ 发作的反应增量。接下来是皮质、顶盖前区、内侧膝状体、下丘的神经元和运动行为。 3. 采集期间的刺激前背景率显示皮质神经元显着减少。在后核反应增加之前，这些背景下降开始在试验系列中得到证实。这些数据强化了先前研究的建议，即后核反应可能依赖于皮质的强直调节。 4. 灭绝似乎在很大程度上是获得的逆转。在试验系列中，皮层和行为首先表现出反应减弱。接下来是内侧膝状体、顶盖前区、后核和下丘神经元。 5.提出的假设是听觉丘系辅助传入系统可能在听觉条件反应获取的早期阶段发挥主要作用。
1. The activity of units in the auditory system of alert, freely moving rats was studies during the acquisition and extinction of a tone-signaled, appetitive classically conditioned response. Responses of neurons in inferior colliculus (N = 28), medial geniculate (N = 32), posterior nucleus of thalamus (N = 28), pretectal region (N = 19), and cortex (N = 100) were studies in 74 rats across 10-trial blocks. 2. During behavioral acquisition, neurons in posterior nucleus of thalamus were the first to show response increments to CS+ onset. They were followed by neurons in cortex, pretectal region, medial geniculate, inferior colliculus and by movement behavior. 3. Prestimulus background rates during acquisition showed significant decrements in cortical neurons. These background decrements began to be evidenced in the trial series before the response increases in posterior nucleus. These data strengthened the suggestion of a previous study that posterior nucleus responses could be dependent on tonic modulation from cortex. 4. Extinction appeared to be largely a reverse of acquisition. Cortex and behavior showed response decrements first in the trial series. They were followed by medial geniculate, pretectal region, posterior nucleus, and inferior colliculus neurons. 5. The hypothesis was advanced that the auditory lemniscal adjunct afferent system may play a primary role in the early phases of auditory conditioned-response acquisition.